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FR 236924

Cat. No. 3091 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3091 has been discontinued.

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说明： Selective PKCε activator
别名： DCP-LA
化学名： 2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid
纯度： ≥99% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for FR 236924

Selective PKCε activator that displays > 7-fold selectivity over other PKC isozymes. Stimulates glutamate release via presynaptic α7 nicotinic receptors on glutamatergic terminals in vitro and enhances cognition in vivo. Brain penetrant.

技术数据 for FR 236924

分子量 308.5
公式 C20H36O2
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 28399-31-7
PubChem ID 9904718
InChI Key CONYTTFKIUJZOF-UHFFFAOYSA-N
Smiles CCCCCC(C2)C2CC1C(CCCCCCCC(O)=O)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for FR 236924

参考文献是支持产品生物活性的出版物。

Yamamoto et al (2005) The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancgng activity of presynaptic α7 acetylcholine receptors on the glutamatergic terminals. Neuroscience 130 207 PMID: 15561436

Kanno et al (2006) The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site. J.Lipid Res. 47 1146 PMID: 16520488

Tanaka and Nishizaki (2003) The newly synthesized linoleic acid derivative FR236924 induces a long lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. Bioorg.Med.Chem.Letts. 13 1037

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关键词: FR 236924, FR 236924 supplier, pkc, pkce, epsilon, protein, kinase, c, a7, α7, alpha7, nAChR, nicotinic, acetylycholine, receptor, ACh, FR236924, DCP-LA, Protein, Kinase, C, Nicotinic, (a7), Receptors, 3091, Tocris Bioscience

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