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FX 1

Cat. No. 6323 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6323 has been discontinued.

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说明： Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
化学名： (5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for FX 1

FX 1 is a Bcl-6 inhibitor (Kd = 3 μM); exhibits 10-fold greater potency than endogenous Bcl-6 corepressors. Disrupts formation of Bcl-6 repression complex. Induces regression of established tumors in mice bearing DLBCL xenograft.

技术数据 for FX 1

分子量 368.82
公式 C14H9ClN2O4S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1426138-42-2
PubChem ID 66488970
InChI Key VISHSGZPGQKEFX-KHPPLWFESA-N
Smiles OC(CCN1C(S/C(C1=O)=C2C(NC3=CC=C(C=C\23)Cl)=O)=S)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for FX 1

参考文献是支持产品生物活性的出版物。

Cardenas et al (2016) Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma. J.Clin.Invest. 126 3351 PMID: 27482887

Cardenas et al (2017) The expanding role of the BCL6 oncoprotein as a cancer therapeutic target. Clin.Cancer Res. 23 885 PMID: 27881582

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关键词: FX 1, FX 1 supplier, FX1, Bcl, family, BCL6, inhibitors, inhibits, B, cell, lymphoma, 6, Diffuse, large, lymphomas, DLBCLs, Cell, CLL, Lymphoma, Bcl-2, Family, 6323, Tocris Bioscience

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该领域的文献

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for FX 1

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.