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FX 1

Cat. No. 6323 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
化学名： (5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for FX 1

FX 1 is a Bcl-6 inhibitor (Kd = 3 μM); exhibits 10-fold greater potency than endogenous Bcl-6 corepressors. Disrupts formation of Bcl-6 repression complex. Induces regression of established tumors in mice bearing DLBCL xenograft.

技术数据 for FX 1

分子量 368.82
公式 C14H9ClN2O4S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1426138-42-2
PubChem ID 66488970
InChI Key VISHSGZPGQKEFX-KHPPLWFESA-N
Smiles OC(CCN1C(S/C(C1=O)=C2C(NC3=CC=C(C=C\23)Cl)=O)=S)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FX 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.88 100

制备储备液 for FX 1

以下数据基于产品分子量 368.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.56 mL 27.11 mL
5 mM 0.54 mL 2.71 mL 5.42 mL
10 mM 0.27 mL 1.36 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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参考文献 for FX 1

参考文献是支持产品生物活性的出版物。

Cardenas et al (2016) Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma. J.Clin.Invest. 126 3351 PMID: 27482887

Cardenas et al (2017) The expanding role of the BCL6 oncoprotein as a cancer therapeutic target. Clin.Cancer Res. 23 885 PMID: 27881582

If you know of a relevant reference for FX 1, please let us know.

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关键词: FX 1, FX 1 supplier, FX1, Bcl, family, BCL6, inhibitors, inhibits, B, cell, lymphoma, 6, Diffuse, large, lymphomas, DLBCLs, Cell, CLL, Lymphoma, Bcl-2, Family, 6323, Tocris Bioscience

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