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GA3-AM

Cat. No. 5407 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5407 has been discontinued.

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说明： Gibberellin-analog (GA3) chemical dimerizer; cell permeable
化学名： (1S,2S,4aR,4bR,7S,9aS,10S,10aR)-1,2,4b,5,6,7,8,9,10,10a-Decahydro-2,7-dihydroxy-1-methyl-8-methylene-13-oxo-4a,1-(epoxymethano)-7,9a-methanobenz[a]azulene-10-acetic acid (acetyloxy)methyl ester
纯度： ≥90% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for GA3-AM

GA3-AM is a Gibberellin-analog (GA3) chemical dimerizer; induces rapid dimerization of GAIs and GID1. GA3-AM crosses the plasma membrane, is cleaved by cytosolic esterase releasing GA3, which then binds GID1- this complex then in turn forms a complex with GAI; this system works on a timescale of seconds (EC50 = 310 nM). GA3 and rapamycin (Cat. No. 1292) chemically inducible dimerization systems are orthogonal. Cell permeable.

技术数据 for GA3-AM

分子量 418.44
公式 C22H26O8
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 1373154-68-7
PubChem ID 56835187
InChI Key IVIYFJSPDLOPEX-SEWSRMJOSA-N
Smiles [H][C@@]12[C@@](C[C@@]3(O)CC2)(CC3=C)[C@@H](C(OCOC(C)=O)=O)[C@]4([H])[C@@]5(C)[C@@H](O)C=C[C@]41OC5=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for GA3-AM

参考文献是支持产品生物活性的出版物。

Lin et al (2013) Rapidly reversible manipulation of molecular activities using dual chemical dimerizers Angew.Chem.Int.Ed.Engl. 52 6450 PMID: 23649661

Miyamoto et al (2012) Rapid and orthogonal logic gating with a gibberellin-induced dimerization system Nat.Chem.Biol. 8 465 PMID: 22446836

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关键词: GA3-AM, GA3-AM supplier, Chemical, dimerizer, cell, permeable, chemically, inducible, dimerization, system, Biochemicals, and, Molecular, Biology, Protein, Dimerizers, 5407, Tocris Bioscience

2 篇 GA3-AM 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GA3-AM 的部分引用包括：

Xi et al (2022) Passage number affects differentiation of sensory neurons from human induced pluripotent stem cells. Sci Rep 12 15869 PMID: 36151116

Yong Chul et al (2019) 5-HT2A receptor activation enhances NMDA receptor-mediated glutamate responses through Src kinase in the dendrites of rat jaw-closing motoneurons. J Physiol 597 2565-2589 PMID: 30919966

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