GKA 50

Cat. No. 5133 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Glucokinase activator

化学名： 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylic acid

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for GKA 50

GKA 50 is a potent glucokinase activator (EC₅₀ = 33 nM). Significantly reduces plasma glucose levels in diabetic rats; stimulates insulin release from mouse islets of Langerhans.

化合物库 for GKA 50

GKA 50 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GKA 50

分子量	464.51
公式	C₂₆H₂₈N₂O₆
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	851884-87-2
PubChem ID	11340230
InChI Key	OCBMECSFDVUYQN-ROUUACIJSA-N
Smiles	O=C(NC3=NC=C(C(O)=O)C=C3)C1=CC(O[C@@H](C)COC)=CC(O[C@@H](C)CC2=CC=CC=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GKA 50

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	46.45	100

制备储备液 for GKA 50

以下数据基于产品分子量 464.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.76 mL	21.53 mL
5 mM	0.43 mL	2.15 mL	4.31 mL
10 mM	0.22 mL	1.08 mL	2.15 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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产品说明书 for GKA 50

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GKA 50

参考文献是支持产品生物活性的出版物。

Coope et al (2006) Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats. Br.J.Pharmacol. 149 328 PMID: 16921397

Johnson et al (2007) Glucokinase activators: molecular tools for studying the physiology of Ins-Secr.g cells. Biochem.Soc.Trans. 35 1208 PMID: 17956314

If you know of a relevant reference for GKA 50, please let us know.

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关键词: GKA 50, GKA 50 supplier, GKA50, glucokinases, hexokinase, IV, HK4, activators, activates, Hexokinases, 5133, Tocris Bioscience

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