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GNF 5

Cat. No. 4908 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)
化学名： N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GNF 5

GNF 5 is a selective, non-ATP competitive allosteric inhibitor of Bcr-Abl (IC50 = 220 nM for wild-type Abl). Binds the myristate-binding site of Abl. Acts in combination with nilotinib to inhibit T315I Bcr-Abl in vitro and in vivo. Analog of GNF 2 (Cat. No. 4399). GNF 5 decreases mitochondrial function in lung cancer cells.

External Portal Information for GNF 5

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GNF 5 is reviewed on the chemical probes website.

化合物库 for GNF 5

GNF 5 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for GNF 5

分子量 418.37
公式 C20H17F3N4O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 778277-15-9
PubChem ID 44129660
InChI Key IIQUYGWWHIHOCF-UHFFFAOYSA-N
Smiles O=C(NCCO)C1=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GNF 5

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.84 100

制备储备液 for GNF 5

以下数据基于产品分子量 418.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.95 mL 23.9 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
10 mM 0.24 mL 1.2 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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参考文献 for GNF 5

参考文献是支持产品生物活性的出版物。

Zhang et al (2010) Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature 463 501 PMID: 20072125

Iacob et al (2011) Allosteric interactions between the myristate- and ATP-site of the Abl kinase. PLoS One 6 e15929 PMID: 21264348

Deng et al (2010) Expanding the diversity of allosteric Bcr-Abl inhibitors. J.Med.Chem. 53 6934 PMID: 20828158

Luttman et al (2021) ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells. Cell Rep. 37 109880 PMID: 34706244

If you know of a relevant reference for GNF 5, please let us know.

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