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GSK 143

Cat. No. 6362 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Syk inhibitor
化学名： 2-[[(3R,4R)-3-Aminotetrahydro-2H-pyran-4-yl]amino]-4-[(4-methylphenyl)amino]-5-pyrimidinecarboxamide dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GSK 143

GSK 143 is a spleen tyrosine kinase (Syk) inhibitor (pIC50 = 7.5). Also inhibits phosphorylated Erk (pIC50 = 7.1). Decreases cell number and viability in chronic lymphocytic leukemia (CCL) cell lines.

化合物库 for GSK 143

GSK 143 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for GSK 143

分子量 415.32
公式 C17H22N6O2.2HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2341796-81-2
PubChem ID 46865656
InChI Key InChIKey=UEHPBSLIDBDMCZ-WICJZZOFSA-N
Smiles CC1=CC=C(C=C1)NC2=NC(N[C@@H]3CCOC[C@@H]3N)=NC=C2C(N)=O.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 143

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 41.53 100
DMSO 41.53 100

制备储备液 for GSK 143

以下数据基于产品分子量 415.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.04 mL 24.08 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
10 mM 0.24 mL 1.2 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for GSK 143

参考文献是支持产品生物活性的出版物。

Liddle et al (2011) Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg.Med.Chem.Lett. 21 6188 PMID: 21903390

Varghese et al (2018) Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia. Br.J.Haematol 182 927 PMID: 28770560

If you know of a relevant reference for GSK 143, please let us know.

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关键词: GSK 143, GSK 143 supplier, GSK143, syk, spleen, tyrosine, kinase, inhibitors, inhibits, chronic, lymphocytic, leukemia, Syk, Kinase, 6362, Tocris Bioscience

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