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GSK 2250665A

Cat. No. 5401 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5401 has been discontinued.

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说明： Itk inhibitor
化学名： trans-4-[[4-[(6-Ethyl-2-benzothiazolyl)amino]-6-(phenylmethyl)-2-pyrimidinyl]amino]cyclohexanol
纯度： ≥97% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for GSK 2250665A

GSK 2250665A is an Itk inhibitor (pKi = 9.2). Exhibits selectivity for Itk over Aurora B kinase and Btk (pIC50 values are 6.4 and 6.5, respectively) and a panel of other kinases. Inhibits IFNγ production in PBMCs.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline

化合物库 for GSK 2250665A

GSK 2250665A is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for GSK 2250665A

分子量 459.61
公式 C26H29N5OS
储存 Store at +4°C
纯度 ≥97% (HPLC)
CAS Number 1246030-96-5
PubChem ID 73352604
InChI Key DPRNXTSMYVCYLJ-XUTJKUGGNA-N
Smiles CCC1=CC=C(N=C(NC3=NC(N[C@H]5CC[C@H](O)CC5)=NC(CC4=CC=CC=C4)=C3)S2)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for GSK 2250665A

参考文献是支持产品生物活性的出版物。

Alder et al (2013) Identification of a novel and selective series of Itk inhibitors via a template-hopping strategy. ACS Med.Chem.Lett. 12 948 PMID: 24900590

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关键词: GSK 2250665A, GSK 2250665A supplier, GSK2250665A, Itk, inducible, T, cell, kinase, inhibitors, inhibits, ITK, 5401, Tocris Bioscience

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