H-7 dihydrochloride

Name: H-7 dihydrochloride
Brand: Tocris Bioscience
SKU: 0542
Rating: 5 (1 reviews)

Cat. No. 0542 4 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Protein kinase inhibitor

化学名： (±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for H-7 dihydrochloride

H-7 dihydrochloride is a protein kinase inhibitor (IC₅₀ values for inhibition of PKA, PKG, PKC and myosin light chain kinase are 3.0, 5.8, 6.0 and 97.0 μM, respectively. H-7 shows antiviral activity against influenza A (IC₅₀ = 10 μM) in vitro. H-7 also inhibits interleukin-stimulated secretion of IgM and blocks PMA-stimulated interleukin 1β production.

化合物库 for H-7 dihydrochloride

H-7 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for H-7 dihydrochloride

分子量	364.29
公式	C₁₄H₁₇N₃O₂S.2HCl
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	108930-17-2
PubChem ID	73332
InChI Key	OARGPFMFRLLKPF-UHFFFAOYSA-N
Smiles	Cl.Cl.CC1CNCCN1S(=O)(=O)C1=CC=CC2=CN=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for H-7 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	36.43	100
	DMSO	7.29	20

制备储备液 for H-7 dihydrochloride

以下数据基于产品分子量 364.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.75 mL	13.73 mL	27.45 mL
5 mM	0.55 mL	2.75 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.75 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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产品说明书 for H-7 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for H-7 dihydrochloride

参考文献是支持产品生物活性的出版物。

Hidaka et al (1984) Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23 5036 PMID: 6238627

Quick et al (1992) The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source. Biochem.Biophys.Res.Commun. 187 657 PMID: 1530632

Ratz et al (1990) Effect of the kinase inhibitor, H-7, on stress, crossbridge phosphorylation, muscle shortening and inositol phosphate production in rabbit arteries. J.Pharmacol.Exp.Ther. 252 253 PMID: 2299593

Kurokawa et al (1990) Inhibitory effect of protein kinase C inhibitor on the replication of influenza type A virus. J.Gen.Virol. 71 2149 PMID: 1698925

Hurme et al (1990) Control of interleukin-1 beta expression by protein kinase C and cyclic adenosine monophosphate in myeloid leukemia cells Blood 76 2198 PMID: 2175219

If you know of a relevant reference for H-7 dihydrochloride, please let us know.

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关键词: H-7 dihydrochloride, H-7 dihydrochloride supplier, Protein, kinase, Broad, Spectrum, inhibitors, inhibits, H7, dihydrochloride, Kinase, Inhibitors, Influenza, Viruses, 0542, Tocris Bioscience

4 篇 H-7 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 H-7 dihydrochloride 的部分引用包括：

Barcomb et al (2013) Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. Front Mol Neurosci 84 834 PMID: 24056996

Ludgate et al (2012) Cyclin-dependent kinase 2 phosphorylates s/t-p sites in the hepadnavirus core protein C-terminal domain and is incorporated into viral capsids. J Virol 86 12237 PMID: 22951823

Zhao et al (2018) TRPV4 Blockade Preserves the Blood-Brain Barrier by Inhibiting Stress Fiber Formation in a Rat Model of Intracerebral Hemorrhage. Front Mol Neurosci 11 97 PMID: 29636662

Belmeguenai and Hansel (2005) A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation. Mol Pharmacol 25 10768 PMID: 16291950

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H7 was studied for its inhibitory role in cAMP dependent protein kinase.

By Anonymous on 12/24/2019

种属： Human

H7 was studied for its inhibitory role in cAMP dependent protein kinase with ICso values of 18 and 16 gM respectively.

Cultures were incubated for 16 hours at 37 ~ in an atmosphere of 5% CO2 and 95% humidified air. 1~tCi of [3H]-thymidine was added to each well and cultures incubated for a further 5 hours. Cells were then harvested onto glass fibre filters, washed and incorporated radioactivity determined by liq- uid scintillation spectrometry.