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说明： Bcl-2 inhibitor. Induces apoptosis
化学名： 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
生物活性 for HA14-1
HA14-1 is a cell-permeable inhibitor of Bcl-2 protein (IC50 ~ 9 μM); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells. Also binds to the antiapoptotic Blc-2 proteins Bcl-XL and Bcl-w.
技术数据 for HA14-1
| 分子量 | 409.23 |
| 公式 | C17H17BrN2O5 |
| 储存 | Desiccate at -20°C |
| CAS Number | 65673-63-4 |
| PubChem ID | 3549 |
| InChI Key | SXJDCULZDFWMJC-UHFFFAOYSA-N |
| Smiles | CCOC(=O)C(C#N)C1C2=C(OC(N)=C1C(=O)OCC)C=CC(Br)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for HA14-1
参考文献 for HA14-1
参考文献是支持产品生物活性的出版物。
Doshi et al (2006) Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. J.Med.Chem. 49 7731 PMID: 17181155
Milella et al (2002) Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia. Blood 99 3461 PMID: 11964319
Wang et al (2000) Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc.Natl.Acad.Sci.U.S.A. 97 7124 PMID: 10860979
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关键词: HA14-1, HA14-1 supplier, Bcl-2, inhibitors, inhibits, induces, apoptosis, Bax, Bcl-XL, Mcl-1, Family, bcl2, inhibitor, 1541, Tocris Bioscience
2 篇 HA14-1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 HA14-1 的部分引用包括：
Qin et al (2010) Coeloglossum viride var. bracteatum extract protects against amyloid toxicity in rat prefrontal cortex neurons. Blood 3 88 PMID: 20369044
Mohan et al (2009) Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells. Brain Res 1283 155 PMID: 19505441
HA14-1 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for HA14-1
