Hesperadin hydrochloride

Cat. No. 3988 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent Aurora kinase B inhibitor

化学名： N-[2,3-Dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-ethanesulfonamide hydrochloride

纯度： ≥99% (HPLC)

引用文献 (2)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Hesperadin hydrochloride

Hesperadin hydrochloride is an ATP-competitive inhibitor of Aurora B kinase (IC₅₀ = 250 nM). Prevents chromosome alignment and segregation; also induces polyploidy and prevents histone H3-Ser10 phosphorylation. Overrides the spindle assembly checkpoint and induces mitotic exit in monastrol- and taxol-treated HeLa cells. Inhibits replication of influenza A and B viral strains (IC₅₀ values range from 0.22 μM to 1.8 μM, dependant on strain), by inhibiting viral RNA transcription and translation

化合物库 for Hesperadin hydrochloride

Hesperadin hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Hesperadin hydrochloride

分子量	553.12
公式	C₂₉H₃₂N₄O₃S.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
PubChem ID	76968689
InChI Key	XMYLEXZLFZAOQN-LXCLTORNSA-N
Smiles	O=C3/C(C2=CC(NS(CC)(=O)=O)=CC=C2N3)=C(C4=CC=CC=C4)\NC1=CC=C(CN5CCCCC5)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Hesperadin hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	55.31	100
	ethanol	27.66	50

制备储备液 for Hesperadin hydrochloride

以下数据基于产品分子量 553.12。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.81 mL	9.04 mL	18.08 mL
5 mM	0.36 mL	1.81 mL	3.62 mL
10 mM	0.18 mL	0.9 mL	1.81 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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产品说明书 for Hesperadin hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Hesperadin hydrochloride

参考文献是支持产品生物活性的出版物。

Hauf et al (2003) The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J.Cell.Biol. 161 281 PMID: 12707311

Jetton et al (2009) The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms. Mol.Microbiol. 72 442 PMID: 19320832

Sessa et al (2005) Mechanism of Aurora B activation by INCENP and inhibition by Hesperadin. Mol.Cell. 18 379 PMID: 15866179

Hu et al (2017) Chemical genomics approach leads to the identification of hesperadin, an aurora B kinase inhibitor, as a broad-spectrum influenza antiviral. Int.J.Mol.Sci. 18 1929 PMID: 28885544

If you know of a relevant reference for Hesperadin hydrochloride, please let us know.

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关键词: Hesperadin hydrochloride, Hesperadin hydrochloride supplier, aurora, B, kinase, inhibitors, inhibits, ATP-competitive, 422513-13-1, antiviral, influenza, virus, Aurora, Kinases, Influenza, Viruses, 3988, Tocris Bioscience

2 篇 Hesperadin hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Hesperadin hydrochloride 的部分引用包括：

Damarys et al (2020) Histone variant H3.3 residue S31 is essential for Xenopus gastrulation regardless of the deposition pathway. Nat Commun 11 1256 PMID: 32152320

Judith et al (2019) DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells. J Lipid Res 60 1787-1800 PMID: 31315900

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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.