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Submit ReviewThe most widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with HBC.
分子量 | 1400 |
公式 | (C6H9O5)7(C3H7O)n |
储存 | Store at RT |
CAS Number | 128446-35-5 |
PubChem ID | 44134771 |
InChI Key | BZRWCHBEBFPRGF-UHFFFAOYSA-N |
Smiles | O[C@@H]1[C@H]8C(COCC(C)O)O[C@H](O[C@H](C(COCC(C)O)O[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O[C@H](C(COCC(C)O)O[C@H](O[C@@H]5C(O)C(O)[C@H](O[C@@H]6C(O)C(O)[C@H](O[C@H](C(COCC(C)O)O[C@H](O8)[C@H]7O)[C@H]7O)O[C@@H]6COCC(C)O)O[C@@H]5COCC(C)O)[C@H]4O)[C@@H]4O)OC3COCC(C)O)[C@H]2O)[C@H]2O)[C@H]1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 140 | 100 |
以下数据基于产品分子量 1400。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 0.71 mL | 3.57 mL | 7.14 mL |
5 mM | 0.14 mL | 0.71 mL | 1.43 mL |
10 mM | 0.07 mL | 0.36 mL | 0.71 mL |
50 mM | 0.01 mL | 0.07 mL | 0.14 mL |
参考文献是支持产品生物活性的出版物。
Frijlink (1991) The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat. Pharm.Res. 8 380 PMID: 2052529
Pitha et al (1986) Hydroxypropyl-β-cyclodextrin: preparation and characterisation; effects on solubility of drugs. Int.J.Pharmacol. 29 73
If you know of a relevant reference for 2-Hydroxypropyl-β-cyclodextrin, please let us know.
关键词: Hydroxypropyl-b-cyclodextrin, Hydroxypropyl-b-cyclodextrin supplier, Solubilization, agent, Reagents, cyclodextrin, Hydroxypropyl-beta-cyclodextrin, Hydroxypropyl-β-cyclodextrin, HBC, Hydroxypropyl-b-cyclodextrin, Biochemicals, and, Molecular, Biology, 0708, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 2-Hydroxypropyl-β-cyclodextrin 的部分引用包括:
Marco et al (2016) Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour. Nat Commun 7 12620 PMID: 27646867
Johnson et al (2012) Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Proc Natl Acad Sci U S A 107 733 PMID: 22554617
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