Imatinib mesylate

Cat. No. 5906 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

别名： Gleevec,CGP 57148B

化学名： 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate

纯度： ≥98% (HPLC)

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Imatinib mesylate

Imatinib mesylate is a potent and selective v-Abl tyrosine kinase inhibitor (IC₅₀ = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis cells. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC₅₀ values are 9.823 and 17.689 μM, respectively).

External Portal Information for Imatinib mesylate

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Imatinib is reviewed on the chemical probes website.

化合物库 for Imatinib mesylate

Imatinib mesylate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Imatinib mesylate

分子量	589.71
公式	C₂₉H₃₁N₇O.CH₄O₃S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	220127-57-1
PubChem ID	123596
InChI Key	YLMAHDNUQAMNNX-UHFFFAOYSA-N
Smiles	CS(O)(=O)=O.CN1CCN(CC1)CC2=CC=C(C(NC3=CC=C(C(NC4=NC=CC(C5=CN=CC=C5)=N4)=C3)C)=O)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Imatinib mesylate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	58.97	100
	DMSO	58.97	100

制备储备液 for Imatinib mesylate

以下数据基于产品分子量 589.71。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.7 mL	8.48 mL	16.96 mL
5 mM	0.34 mL	1.7 mL	3.39 mL
10 mM	0.17 mL	0.85 mL	1.7 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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产品说明书 for Imatinib mesylate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Imatinib mesylate

参考文献是支持产品生物活性的出版物。

Buchdunger et al (1996) Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 56 100 PMID: 8548747

Juurikivi et al (2005) Inhibition of c-kit tyrosine kinase by ima. mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis. Ann.Rheum.Dis. 64 1126 PMID: 16014680

Dyall et al (2014) Repurposing of clinically developed drugs for treatment of Middle East Respiratory Syndrome coronavirus infection. Antimicrob.Agents Chemother. 58 4885 PMID: 24841273

If you know of a relevant reference for Imatinib mesylate, please let us know.

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3 篇 Imatinib mesylate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Imatinib mesylate 的部分引用包括：

So-Youn et al (2019) Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies. Cell Death Differ 26 502-515 PMID: 29988075

Hauke et al (2020) A Whole Genome-Wide Arrayed CRISPR Screen in Primary Organ Fibroblasts to Identify Regulators of Kidney Fibrosis. SLAS Discov 25 591-604 PMID: 32425084

Sue A et al (2020) Long-term imatinib diminishes ovarian reserve and impacts embryo quality. J Assist Reprod Genet 37 1459-1466 PMID: 32372302

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