Indocyanine green

Cat. No. 7510 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Near-infrared (NIR) fluorescent dye; suitable for in vivo imaging

别名： ICG

化学名： Sodium 4-(2-((1E,3E,5E,7Z)-7-(1,1-Dimethyl-3-(4-sulfonatobutyl)-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-3-yl)butane-1-sulfonate

纯度： ≥95% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Indocyanine green

Key information: Indocyanine green (ICG) is a near-infrared (NIR) fluorescent dye suitable for in vivo imaging.

Application: Fluorescence microscopy, in vivo imaging.

Properties and Photophysical Data: Indocyanine green is a NIR fluorescent dye operating in the 700-900 nm wavelength range. It binds to β-lipoproteins, particularly albumin, in plasma and exhibits fluorescence emission in the shortwave infrared window (SWIR; 1,000-2,000 nm) which enables in vivo imaging, including intravital microscopy, non-invasive real-time imaging in blood and lymph vessels, and imaging of hepatobiliary clearance. Imaging of indocyanine green in SWIR shows increased sensitivity, contrast, and resolution of fine anatomical structures over NIR. Excitation and emission maxima (λ) are 787 nm and 815 nm, respectively; quantum yield = 0.14; extinction coefficient = 223,000 M^-1cm^-1; A280 correction factor = 0.07.

This product is supplied with a high degree of hydration and may contain residual inorganic salts, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

Optical Data for Indocyanine green

Emission Color	Near-IR
Brightness
λ_abs	787 nm
λ_em	815 nm
Extinction Coefficient (ε)	223000 M^-1cm^-1
Quantum Yield (φ)	0.14
Closest Laser line	785 nm
pH Sensitivity	No
Correction Factor 280	0.07
Application	Fluorescence Microscopy, in vivo Imaging

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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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技术数据 for Indocyanine green

分子量	774.97
公式	C₄₃H₄₇N₂O₆S₂Na
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	3599-32-4
PubChem ID	45101199
InChI Key	MOFVSTNWEDAEEK-UHFFFAOYSA-M
Smiles	CC1(/C(N(C2=C1C3=CC=CC=C3C=C2)CCCCS(=O)(O[Na])=O)=C/C=C/C=C/C=C/C4=[N+](C5=C(C4(C)C)C6=CC=CC=C6C=C5)CCCCS([O-])(=O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Indocyanine green

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	15.5	20
	water	38.75	50

制备储备液 for Indocyanine green

以下数据基于产品分子量 774.97。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	2.58 mL	12.9 mL	25.81 mL
2.5 mM	0.52 mL	2.58 mL	5.16 mL
5 mM	0.26 mL	1.29 mL	2.58 mL
25 mM	0.05 mL	0.26 mL	0.52 mL

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产品说明书 for Indocyanine green

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Indocyanine green

参考文献是支持产品生物活性的出版物。

Starosolski et al (2017) Indocyanine green fluorescence in second near-infrared (NIR-II) window. PLoS One 12 e0187563 PMID: 29121078

Carr et al (2018) Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green. Proc.Natl.Acad.Sci.U.S.A. 115 4465 PMID: 29626132

Cosco et al (2021) Photophysical properties of indocyanine green in the shortwave infrared region. ChemPhotoChem. 5 727 PMID: 34504949

Lee et al (2021) Surgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study. Sci.Rep. 11 9997 PMID: 33976314

Li et al (2019) Recent progress in small-molecule near-IR probes for bioimaging. Trends Chem. 1 224 PMID: 32864595

If you know of a relevant reference for Indocyanine green, please let us know.

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关键词: Indocyanine green, Indocyanine green supplier, NIR, near, infrared, short, wave, SWIR, fluorescent, dye, fluorescence, real, time, imaging, labeling, labelling, ICG, Cyanine, Dyes, (Cy, Dyes), Near, Infrared, (NIR), Fluorescent, 7510, Tocris Bioscience

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