INDY

Cat. No. 4997 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： DYRK1A/B inhibitor

化学名： (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone

纯度： ≥98% (HPLC)

说明书

引用文献 (5)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for INDY

INDY is a DYRK1A/B inhibitor (IC₅₀ values are 0.23 and 0.24 μM, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY (Cat. No. 4998).

化合物库 for INDY

INDY is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for INDY

分子量	235.3
公式	C₁₂H₁₃NO₂S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1169755-45-6
PubChem ID	69538603
InChI Key	GCSZJMUFYOAHFY-UHFFFAOYSA-N
Smiles	O=C(C)/C=C1SC2=CC=C(O)C=C2N\1CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for INDY

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	23.53	100

制备储备液 for INDY

以下数据基于产品分子量 235.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.25 mL	21.25 mL	42.5 mL
5 mM	0.85 mL	4.25 mL	8.5 mL
10 mM	0.42 mL	2.12 mL	4.25 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

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产品说明书 for INDY

分析证书/产品说明书

化学品安全技术说明书

参考文献 for INDY

参考文献是支持产品生物活性的出版物。

Pozo et al (2013) Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. J.Clin.Invest. 123 2475 PMID: 23635774

Ogawa et al (2010) Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat.Commun. 1 86 PMID: 20981014

If you know of a relevant reference for INDY, please let us know.

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关键词: INDY, INDY supplier, INDY, downs, syndrome-related, kinase, Dyrk1A/B, inhibitors, inhibits, tau, phosphorylation, hyperphosphorylation, calcineurin, NFAT, signalling, self-renewal, neural, stem, cells, NSCs, Microtubules, Stem, Cell, Proliferation, DYRK, 4997, Tocris Bioscience

5 篇 INDY 的引用文献

引用文献是使用了 Tocris 产品的出版物。 INDY 的部分引用包括：

Wahl et al (2018) Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function. BMC Genomics 19 795 PMID: 30390632

Kim et al (2016) A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition. Dis Model Mech 9 839 PMID: 27483355

Peng et al (2020) Pharmacologic and genetic approaches define human pancreatic β cell mitogenic targets of DYRK1A inhibitors. JCI Insight 5 PMID: 31821176

Seu et al (2015) Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection. J Virol 89 6656 PMID: 25878110

Wang et al (2015) A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication. Nat Med 21 383 PMID: 25751815

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