IRAK1/4 Inhibitor I

Name: IRAK1/4 Inhibitor I
Brand: Tocris Bioscience
SKU: 5665
Rating: 5 (1 reviews)

Cat. No. 5665 1 次引用 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： IRAK4 and IRAK1 inhibitor

化学名： N-[1-[2-(4-Morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitrobenzamide

纯度： ≥98% (HPLC)

说明书

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for IRAK1/4 Inhibitor I

IRAK1/4 Inhibitor I is an IRAK4 and IRAK1 inhibitor (IC₅₀ values are 0.2 and 0.3 μM, respectively).

化合物库 for IRAK1/4 Inhibitor I

IRAK1/4 Inhibitor I is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for IRAK1/4 Inhibitor I

分子量	395.41
公式	C₂₀H₂₁N₅O₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	509093-47-4
PubChem ID	11983295
InChI Key	QTCFYQHZJIIHBS-UHFFFAOYSA-N
Smiles	O=C(NC1=NC(C=CC=C2)=C2N1CCN3CCOCC3)C4=CC=CC([N+]([O-])=O)=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for IRAK1/4 Inhibitor I

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	7.91	20

制备储备液 for IRAK1/4 Inhibitor I

以下数据基于产品分子量 395.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	12.65 mL	63.23 mL	126.45 mL
1 mM	2.53 mL	12.65 mL	25.29 mL
2 mM	1.26 mL	6.32 mL	12.65 mL
10 mM	0.25 mL	1.26 mL	2.53 mL

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产品说明书 for IRAK1/4 Inhibitor I

分析证书/产品说明书

化学品安全技术说明书

参考文献 for IRAK1/4 Inhibitor I

参考文献是支持产品生物活性的出版物。

Powers et al (2006) Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg.Med.Chem.Lett. 16 2842 PMID: 16563752

If you know of a relevant reference for IRAK1/4 Inhibitor I, please let us know.

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关键词: IRAK1/4 Inhibitor I, IRAK1/4 Inhibitor I supplier, IRAK1/4, inhibitors, inhibits, I, interleukin-1, receptor, associated, kinase, IRAK, 5665, Tocris Bioscience

1 篇 IRAK1/4 Inhibitor I 的引用文献

引用文献是使用了 Tocris 产品的出版物。 IRAK1/4 Inhibitor I 的部分引用包括：

Shahid et al (2021) SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut. Cell Mol Gastroenterol Hepatol 13 425-440 PMID: 34563711

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