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JP-2-196

Cat. No. 8046 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： RNF126 chemical handle
化学名： 1-(4-Methoxyphenyl)-4-(1-piperazinyl)-2-butene-1,4-dione hydrochloride
纯度： ≥95% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for JP-2-196

JP-2-196 is a covalent RNF126 chemical handle that binds to several other RING E3 ubiquitin ligases including RNF14, RNF40, RNF219, MID2, and LRSAM. By facilitating E3 ligase recruitment, JP-2-196 induces proteasomal degradation of diverse target proteins. It serves as a modular scaffold for the design and synthesis of molecular glue degraders.

Usage Guidelines for JP-2-196

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for JP-2-196

分子量 310.78
公式 C15H18N2O3.HCl
储存 Store at -20°C
纯度 ≥95% (HPLC)
InChI Key KITOUXXMDYKXJY-UHDJGPCESA-N
Smiles O=C(C1=CC=C(C=C1)OC)/C=C/C(N2CCNCC2)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for JP-2-196

参考文献是支持产品生物活性的出版物。

Toriki et al (2023) Rational chemical design of molecular glue Degraders. ACS Cent.Sci. 9 915 PMID: 37252349

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关键词: JP-2-196, JP-2-196 supplier, JP2-196, e3, ligase, RNF114, ligands, targeted, protein, TPD, Degrader, Degraders, molecular, glue, Ubiquitin, E3, Ligases, Molecular, Glues, 8046, Tocris Bioscience

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