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JX 06

Cat. No. 5845 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor
化学名： Bis(morpholinothiocarbonyl) disulfide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for JX 06

JX 06 is a potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively). Exhibits selectivity for PDK1/2/3 over PDK4 and a panel of 323 other kinases. Suppresses A549 lung cancer cell proliferation in vitro. Reduces tumor volume of A549 xenografts in mice.

技术数据 for JX 06

分子量 324.51
公式 C10H16N2O2S4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 729-46-4
PubChem ID 12892
InChI Key KKVYOWPPMNSLCP-UHFFFAOYSA-N
Smiles S=C(SSC(N1CCOCC1)=S)N2CCOCC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JX 06

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.45 100

制备储备液 for JX 06

以下数据基于产品分子量 324.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.82 mL
5 mM 0.62 mL 3.08 mL 6.16 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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参考文献 for JX 06

参考文献是支持产品生物活性的出版物。

Sun et al (2015) JX06 selectively inhibits pyruvate dehydrogenase kinase PDK1 by a covalent cysteine modification. Cancer Res. 75 4923 PMID: 26483203

If you know of a relevant reference for JX 06, please let us know.

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关键词: JX 06, JX 06 supplier, NSC402538, JX06, potent, selective, PDK1, PDK2, PDK3, pyruvate, dehydrogenase, kinases, inhibitors, inhibits, Other, Kinases, 5845, Tocris Bioscience

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