K 252a

Cat. No. 1683 7 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Protein kinase inhibitor

别名： SF 2370

化学名： (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester

纯度： ≥98% (HPLC)

说明书

引用文献 (7)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for K 252a

K 252a is a non-selective protein kinase inhibitor; analog of staurosporine (Cat.No. 1285). Inhibits PKC (IC₅₀ = 32.9 nM), Ca²⁺/calmodulin-stimulated phosphodiesterases (IC₅₀ = 1.3 - 2.9 μM), MLCK (K_i = 20 nM) and receptor tyrosine kinases. Inhibits the oncogenic properties of MET; prevents autophosphorylation and activation of downstream effectors (MAPK, Akt).

技术数据 for K 252a

分子量	467.48
公式	C₂₇H₂₁N₃O₅
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	99533-80-9
PubChem ID	3035817
InChI Key	KOZFSFOOLUUIGY-SOLYNIJKSA-N
Smiles	[H][C@](C[C@]8(O)[C@@](OC)=O)(O[C@]78C)N5C3=C2N7C1=CC=CC=C1C2=C(CNC6=O)C6=C3C4=CC=CC=C45

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for K 252a

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	11.69	25

制备储备液 for K 252a

以下数据基于产品分子量 467.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.25 mM	8.56 mL	42.78 mL	85.57 mL
1.25 mM	1.71 mL	8.56 mL	17.11 mL
2.5 mM	0.86 mL	4.28 mL	8.56 mL
12.5 mM	0.17 mL	0.86 mL	1.71 mL

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产品说明书 for K 252a

分析证书/产品说明书

化学品安全技术说明书

参考文献 for K 252a

参考文献是支持产品生物活性的出版物。

Kase et al (1986) K-252a, a potent inhibitor of protein kinase C from microbial origin. J.Antibiot. 39 1059 PMID: 3759657

Knusel and Hefti (1992) K-252 compounds: modulators of neurotrophin signal transduction. J.Neurochem. 59 1987 PMID: 1431889

Morotti et al (2002) K252a inhibits the oncogenic properties of Met, the HGF receptor. Oncogene 21 4885 PMID: 12118367

Ruegg and Burgess (1989) Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. TiPS 10 218 PMID: 2672462

If you know of a relevant reference for K 252a, please let us know.

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