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KB SRC 4

Cat. No. 4660 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective c-Src inhibitor
化学名： 1-[3-[1-([1,1'-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for KB SRC 4

KB SRC 4 is a potent and selective c-Src inhibitor (Ki = 44 nM); does not inhibit c-Abl at concentrations up to 125 μM. Selective between Src family members (Kd values are 86, 160, 240, 720, 3200, 4400, and >40,000 nM for c-Src, Lck, Fgr, Yes, Lyn, Hck and Fyn respectively). Significantly inhibits cell growth in 4T1 mammary carcinoma tumor cells.

化合物库 for KB SRC 4

KB SRC 4 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for KB SRC 4

分子量 555.03
公式 C32H23ClN8
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1380088-03-8
PubChem ID 73349077
InChI Key UHIZYQVRKSWIFO-UHFFFAOYSA-N
Smiles NC1=C2C(N(C4=CC=CC(C5=CN=NN5CC6=CC(C7=CC=CC=C7)=CC=C6)=C4)N=C2C3=CC=C(Cl)C=C3)=NC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for KB SRC 4

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 11.1 20

制备储备液 for KB SRC 4

以下数据基于产品分子量 555.03。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 9.01 mL 45.04 mL 90.09 mL
1 mM 1.8 mL 9.01 mL 18.02 mL
2 mM 0.9 mL 4.5 mL 9.01 mL
10 mM 0.18 mL 0.9 mL 1.8 mL

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参考文献 for KB SRC 4

参考文献是支持产品生物活性的出版物。

Brandvold et al (2012) Development of a highly selective c-Src kinase inhibitor. ACS Chem.Biol. 7 1393 PMID: 22594480

If you know of a relevant reference for KB SRC 4, please let us know.

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关键词: KB SRC 4, KB SRC 4 supplier, KBSRC4, c-Src, Src, kinases, inhibitors, inhibits, 4T1, mammary, carcinoma, tumor, cells, breast, cancer, non-receptor, tyrosine, Kinases, 4660, Tocris Bioscience

4 篇 KB SRC 4 的引用文献

引用文献是使用了 Tocris 产品的出版物。 KB SRC 4 的部分引用包括：

Dominique et al (2021) Biological characterization of ligands targeting the human CC chemokine receptor 8 (CCR8) reveals the biased signaling properties of small molecule agonists. Biochem Pharmacol 188 114565 PMID: 33872569

Carmona et al (2016) Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE. Oncogene 35 5155 PMID: 26996666

Kim et al (2014) An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. Mol Cell Biol 34 4368 PMID: 25312644

Joseph R et al (2020) The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC. Neurobiol Pain 7 100039 PMID: 31909296

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