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Submit ReviewKetamine hydrochloride
说明： Non-competitive NMDA receptor antagonist
化学名： 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Ketamine hydrochloride
Ketamine hydrochloride is a non-competitive NMDA receptor antagonist (EC50 values are 13.6 and 17.6 μM for GluN1/GluN2A (formally NR1 and NR2A, respectively) and GluN1/GluN2B (formally NR1 and NR2B, respectively) subunit combinations respectively). Dissociative anesthetic.
S-enantiomer and Active metabolite also available.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions. .
技术数据 for Ketamine hydrochloride
| 分子量 | 274.19 |
| 公式 | C13H16ClNO.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1867-66-9 |
| PubChem ID | 15851 |
| InChI Key | VCMGMSHEPQENPE-UHFFFAOYSA-N |
| Smiles | O=C1C(C2=CC=CC=C2Cl)(NC)CCCC1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ketamine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 27.42 | 100 |
制备储备液 for Ketamine hydrochloride
以下数据基于产品分子量 274.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.65 mL | 18.24 mL | 36.47 mL |
| 5 mM | 0.73 mL | 3.65 mL | 7.29 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.65 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
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产品说明书 for Ketamine hydrochloride
参考文献 for Ketamine hydrochloride
参考文献是支持产品生物活性的出版物。
Anis et al (1983) The dissociative anaesthetics, KA and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br.J.Pharmacol. 79 565 PMID: 6317114
Pallares et al (1995) Effects of KA, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats. Physiol.Behav. 57 389 PMID: 7716221
Liu et al (2001) Modulation of NMDA receptor function by KA and magnesium: part I. Anesth.Pharmacol. 92 1173
If you know of a relevant reference for Ketamine hydrochloride, please let us know.
关键词: Ketamine hydrochloride, Ketamine hydrochloride supplier, Non-competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Dissociative, anesthetic, psychoplastogen, Ketamine, and, Metabolites, 3131, Tocris Bioscience
1 篇 Ketamine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ketamine hydrochloride 的部分引用包括：
Rzeski et al (2001) Glutamate antagonists limit tumor growth. Oncotarget 98 6372 PMID: 11331750
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Ketamine hydrochloride 的评论
平均评分: 5 (Based on 1 Review.)
Have you used Ketamine hydrochloride?
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Anaesthetic and antidepressant drug - works well.
By
Luiz Alexandre Magno on 11/11/2022
分析类型： In Vivo
种属： Mouse
Ketamine hydrochloride from Tocris has been used in my lab as a potent intraperitoneal anaesthetic for general surgery and also as a candidate drug for treating depression. It has worked well so far. The image shows data from mice anesthetized with an intraperitoneal injection of ketamine solution at 80 mg/kg. The drug was diluted in sterile saline.
Ketamine should be mixed with xylazine for anaesthesia.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.