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Submit Review(S)-(+)-Ketamine hydrochloride
Description: NMDA receptor antagonist; enantiomer of ketamine hydrochloride (Cat. No. 3131); neuroprotective
Chemical Name: (S)-(+)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for (S)-(+)-Ketamine hydrochloride
(S)-(+)-Ketamine hydrochloride is a NMDA receptor antagonist. Displays neuroprotective efficacy in vitro.
Racemate also available.
Technical Data for (S)-(+)-Ketamine hydrochloride
| M. Wt | 274.19 |
| Formula | C13H16ClNO.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 33643-47-9 |
| PubChem ID | 44632368 |
| InChI Key | VCMGMSHEPQENPE-ZOWNYOTGSA-N |
| Smiles | O=C1[C@](C2=CC=CC=C2Cl)(NC)CCCC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (S)-(+)-Ketamine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 27.42 | 100 | |
| DMSO | 27.42 | 100 |
Preparing Stock Solutions for (S)-(+)-Ketamine hydrochloride
The following data is based on the product molecular weight 274.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.65 mL | 18.24 mL | 36.47 mL |
| 5 mM | 0.73 mL | 3.65 mL | 7.29 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.65 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
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Product Datasheets for (S)-(+)-Ketamine hydrochloride
References for (S)-(+)-Ketamine hydrochloride
References are publications that support the biological activity of the product.
Ryder et al (1978) Comparative pharmacology of the optical isomers of KA in mice. Eur.J.Pharmacol. 49 15 PMID: 658124
Proescholdt et al (2001) Neuroprotection of S(+) KA isomer in global forebrain ischemia. Brain Res. 904 245 PMID: 11406122
Benrath et al (2005) Low dose of S(+)-KA prevents long-term potentiation in pain pathways under strong opioid analgesia in the rat spinal cord in vivo. Br.J.Anaesth. 95 518 PMID: 16113037
If you know of a relevant reference for (S)-(+)-Ketamine hydrochloride, please let us know.
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Keywords: (S)-(+)-Ketamine hydrochloride, (S)-(+)-Ketamine hydrochloride supplier, nmda, nmdar, antagonists, NMDA, Receptors, Ketamine, and, Metabolites, 4379, Tocris Bioscience
Citations for (S)-(+)-Ketamine hydrochloride
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Literature in this Area
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