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KG 5

Cat. No. 5260 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
化学名： 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for KG 5

KG 5 is a PDGFRβ and B-Raf allosteric inhibitor. Also inhibits c-Raf, FLT3 and KIT. Disrupts blood vessel formation in zebrafish embryos and inhibits angiogenesis in a mouse angiogenesis model. Inhibits growth of renal and pancreatic tumors in mice. Also arrests cells in prometaphase. Orally available.

化合物库 for KG 5

KG 5 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for KG 5

分子量 459.45
公式 C20H16F3N7OS
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 877874-85-6
PubChem ID 53328059
InChI Key CMYHZFCJPORPHY-UHFFFAOYSA-N
Smiles NC1=NC(SC)=NC(OC(C=C4)=CC=C4C3=NN=C(N3)NC2=CC(C(F)(F)F)=CC=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for KG 5

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 45.94 100
ethanol 45.94 100

制备储备液 for KG 5

以下数据基于产品分子量 459.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.88 mL 21.77 mL
5 mM 0.44 mL 2.18 mL 4.35 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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参考文献 for KG 5

参考文献是支持产品生物活性的出版物。

Murphy et al (2010) Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc.Natl.Acad.Sci.U.S.A. 107 4299 PMID: 20154271

Mielgo et al (2011) A MEK-independent role for CRAF in mitosis and tumor progression. Nat.Med. 17 PMID: 22081024

If you know of a relevant reference for KG 5, please let us know.

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关键词: KG 5, KG 5 supplier, KG5, KIT, FLT3, B-Raf, C-Raf, PDGFRbeta, PDGFRB, β, inhibitors, inhibits, anticancers, angiogenesis, antiangiogenics, PDGFR, Other, RTKs, Raf, Kinase, Antiangiogenics, 5260, Tocris Bioscience

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