KN 93 phosphate

Name: KN 93 phosphate
Brand: Tocris Bioscience
SKU: 5215
Rating: 5 (1 reviews)

Cat. No. 5215 5 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278)

化学名： N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide phosphate

纯度： ≥98% (HPLC)

说明书

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for KN 93 phosphate

KN 93 phosphate is a CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).

技术数据 for KN 93 phosphate

分子量	599.03
公式	C₂₆H₂₉ClN₂O₄S.H₃PO₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1188890-41-6
PubChem ID	16760530
InChI Key	NNKJTPOXLIILMB-IPZCTEOASA-N
Smiles	O=S(N(CCO)C1=C(CN(C)C/C=C/C3=CC=C(Cl)C=C3)C=CC=C1)(C2=CC=C(OC)C=C2)=O.O=P(O)(O)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for KN 93 phosphate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	5.99	10

制备储备液 for KN 93 phosphate

以下数据基于产品分子量 599.03。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	16.69 mL	83.47 mL	166.94 mL
0.5 mM	3.34 mL	16.69 mL	33.39 mL
1 mM	1.67 mL	8.35 mL	16.69 mL
5 mM	0.33 mL	1.67 mL	3.34 mL

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产品说明书 for KN 93 phosphate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for KN 93 phosphate

参考文献是支持产品生物活性的出版物。

Anderson et al (1998) KN-93, an inhibitor of multifunctional Ca²⁺/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J.Pharmacol.Exp.Ther. 287 996 PMID: 9864285

Sumi et al (1991) The newly synthesized selective Ca²⁺/calmodulin dependent protein kinase II inhibitor KN-93 reduces DA content in PC12h cells. Biochem.Biophys.Res.Comm. 181 968 PMID: 1662507

Rezazadeh et al (2006) KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 317 292 PMID: 16368898

Bruno et al (2010) Microwave-assisted synthesis of KN-93, a potent and selective inhibitor or Ca²⁺/Calmoduline-dependent protein kinase II. Synthesis 24 4193

If you know of a relevant reference for KN 93 phosphate, please let us know.

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关键词: KN 93 phosphate, KN 93 phosphate supplier, KN93, phosphate, CaM, Kinase, II, kinases, Calmodulin-Activated, calmodulin-dependent, Protein, Ca2+, Binding, modulators, Calcium, Signaling, Signalling, inhibitors, inhibits, water, soluble, 5215, Tocris Bioscience

5 篇 KN 93 phosphate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 KN 93 phosphate 的部分引用包括：

Zhang et al (2018) Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models. Nat Commun 9 4272 PMID: 30323233

Fading et al (2017) Synaptic activity suppresses expression of neurogenic differentiation factor 2 in an NMDA receptor-dependent manner. Synapse 71 PMID: 28524267

Mark et al (2013) Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. Proc Natl Acad Sci U S A 110 E1026-34 PMID: 23431153

Kurt F et al (2019) Effects of HIV-1 Tat on oligodendrocyte viability are mediated by CaMKIIβ-GSK3β interactions. J Neurochem 149 98-110 PMID: 30674062

Mauger et al (2016) Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity. Neuron 92 1266 PMID: 28009274

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KN93 phosphate inhibits HOCl-LDL-reduced Ca2+ transient amplitude in cardiomyocytes.

By Christopher Trummer on 10/22/2018

分析类型： In Vitro

种属： Other

细胞系/组织： Cardiomyocytes

Guinea pig ventricular cardiomyocytes were incubated with KN93 phosphate (5 µM, 30 min) prior to HOCl-LDL (250 µg/ml, 14 h) addition followed by loading of cells with Fura-2AM. Cells were stimulated at a 1 Hz frequency and Ca2+ transient (CaT) amplitude was analyzed. KN93 phosphate significantly inhibited HOCl-LDL-reduced CaT amplitude