LCB 03-0110 dihydrochloride

Name: LCB 03-0110 dihydrochloride
Brand: Tocris Bioscience
SKU: 5592
Rating: 4 (1 reviews)

Cat. No. 5592 3 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

化学名： 3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for LCB 03-0110 dihydrochloride

LCB 03-0110 dihydrochloride is a potent c-Src kinase inhibitor (IC₅₀ = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.

化合物库 for LCB 03-0110 dihydrochloride

LCB 03-0110 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for LCB 03-0110 dihydrochloride

分子量	490.45
公式	C₂₄H₂₃N₃O₂S.2HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1962928-28-4
PubChem ID	121513872
InChI Key	OEWGAUGZPPUIPF-UHFFFAOYSA-N
Smiles	OC1=CC=CC(NC2=CC=NC3=C2SC(C4=CC=CC(CN5CCOCC5)=C4)=C3)=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LCB 03-0110 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	49.05	100
	DMSO	49.05	100

制备储备液 for LCB 03-0110 dihydrochloride

以下数据基于产品分子量 490.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.19 mL	20.39 mL
5 mM	0.41 mL	2.04 mL	4.08 mL
10 mM	0.2 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.2 mL	0.41 mL

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产品说明书 for LCB 03-0110 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for LCB 03-0110 dihydrochloride

参考文献是支持产品生物活性的出版物。

Sun et al (2012) LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J.Pharmacol.Exp.Ther. 340 510 PMID: 22128347

If you know of a relevant reference for LCB 03-0110 dihydrochloride, please let us know.

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关键词: LCB 03-0110 dihydrochloride, LCB 03-0110 dihydrochloride supplier, src, kinase, inhibitors, inhibits, potent, discoidin, domain, receptor, DDR, wound, healing, Bruton's, tyrosine, BTK, syk, anti-inflammatory, Src, Kinases, Brutons, Tyrosine, Kinase, (BTK), Syk, Other, RTKs, 5592, Tocris Bioscience

3 篇 LCB 03-0110 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 LCB 03-0110 dihydrochloride 的部分引用包括：

Xiaoguang et al (2020) Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases. Hum Mol Genet 29 2882-2898 PMID: 32776088

Fowler et al (2019) Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration. Drugs R D 19 149 PMID: 30919310

Mogami (2018) Collagen Type 1 accelerates healing of ruptured fetal membranes. Sci Rep 8 696 PMID: 29330408

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