LFM-A13

Cat. No. 1300 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, selective BTK inhibitor

化学名： 2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide

纯度： ≥98% (HPLC)

说明书

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for LFM-A13

LFM-A13 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC₅₀ value of 2.5 μM and has no activity on other protein kinases ( including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 μM.

化合物库 for LFM-A13

LFM-A13 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for LFM-A13

分子量	360
公式	C₁₁H₈Br₂N₂O₂
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	62004-35-7
PubChem ID	54676905
InChI Key	UVSVTDVJQAJIFG-VURMDHGXSA-N
Smiles	C\C(O)=C(/C#N)C(=O)NC1=C(Br)C=CC(Br)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LFM-A13

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	36	100

制备储备液 for LFM-A13

以下数据基于产品分子量 360。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.78 mL	13.89 mL	27.78 mL
5 mM	0.56 mL	2.78 mL	5.56 mL
10 mM	0.28 mL	1.39 mL	2.78 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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产品说明书 for LFM-A13

分析证书/产品说明书

化学品安全技术说明书

参考文献 for LFM-A13

参考文献是支持产品生物活性的出版物。

Crosby and Pool (2002) Interaction of Bruton's tyrosine kinase and protein kinase Cθ in platelets. J.Biol.Chem. 277 9958 PMID: 11788586

Mahajan et al (1999) Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide]. J.Biol.Chem. 274 9587 PMID: 10092645

Vassilev et al (1999) Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. J.Biol.Chem. 274 1646 PMID: 9880544

If you know of a relevant reference for LFM-A13, please let us know.

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关键词: LFM-A13, LFM-A13 supplier, Potent, selective, BTK, inhibitors, inhibits, Brutons, Tyrosine, Kinases, LFMA13, Kinase, (BTK), 1300, Tocris Bioscience