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Submit ReviewLIMKi 3
说明： Potent LIM kinase inhibitor; antitumor
别名： BMS 5
化学名： N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide
纯度： ≥98% (HPLC)
生物活性 for LIMKi 3
LIMKi 3 is a potent LIM kinase inhibitor (IC50 values are 7 and 8 nM for LIMK1 and LIMK2 respectively). Inhibits cofilin phosphorylation in MDA-MB-231 breast cancer cells. Reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.
化合物库 for LIMKi 3
LIMKi 3 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。
技术数据 for LIMKi 3
| 分子量 | 431.29 |
| 公式 | C17H14Cl2F2N4OS |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1338247-35-0 |
| PubChem ID | 56965901 |
| InChI Key | IVUGBSGLHRJSSP-UHFFFAOYSA-N |
| Smiles | FC(F)C1=NN(C2=C(Cl)C=CC=C2Cl)C(C3=CN=C(NC(C(C)C)=O)S3)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for LIMKi 3
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 43.13 | 100 |
制备储备液 for LIMKi 3
以下数据基于产品分子量 431.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.59 mL | 23.19 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.64 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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产品说明书 for LIMKi 3
参考文献 for LIMKi 3
参考文献是支持产品生物活性的出版物。
Ross-Macdonald et al (2008) Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol.Cancer Ther. 7 3490 PMID: 19001433
Scott et al (2010) LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J.Cell Biol. 191 169 PMID: 20876278
Sparrow et al (2012) The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for Schwann cell myelination. J.Neurosci. 32 5284 PMID: 22496574
If you know of a relevant reference for LIMKi 3, please let us know.
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关键词: LIMKi 3, LIMKi 3 supplier, LIMKi3, potent, lim, kinases, inhibitors, inhibits, antitumor, BMS5, BMS, 5, LIMK, 4745, Tocris Bioscience
5 篇 LIMKi 3 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LIMKi 3 的部分引用包括：
Georgouli et al (2019) Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment. Cell 176 757 PMID: 30712866
Michael R et al (2021) The Wdr1-LIMK-Cofilin Axis Controls B Cell Antigen Receptor-Induced Actin Remodeling and Signaling at the Immune Synapse. Front Cell Dev Biol 9 649433 PMID: 33928084
Johannes et al (2021) Arhgef6 (alpha-PIX) cytoskeletal regulator signals to GTPases and Cofilin to couple T cell migration speed and persistence. J Leukoc Biol 110 839-852 PMID: 33527537
William M et al (2018) The actin filament bundling protein α-actinin-4 actually suppresses actin stress fibers by permitting actin turnover. J Biol Chem 293 14520-14533 PMID: 30049798
Marie et al (2019) Cyclosporine A inhibits MRTF-SRF signaling through Na+/K+ ATPase inhibition and actin remodeling. FASEB Bioadv 1 561-578 PMID: 32123851
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