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Lin28 1632

Cat. No. 6068 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor
化学名： N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Lin28 1632

Lin28 1632 is an RNA binding protein Lin28 inhibitor (IC50 = 8 μM). Lin28 1632 blocks binding of Lin28 to let-7 pre-micro RNA. Lin28 1632 inhibits stemness and induces differentiation of murine ESCs. Lin28 1632 increases let-7 miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Lin28 1632 inhibits growth of tumor cell lines and tumor-sphere formation in vitro. Lin28 1632 also inhibits growth of tumor xenografts in mice by enhancing T cell-mediated antitumor immunity. Lin28 1632 is also bromodomain inhibitor. Lin28 1632 inhibits tumor growth and metastasis in vivo in immunodeficient orthotopic mouse models of human breast cancer cell MDA-MB-231.

化合物库 for Lin28 1632

Lin28 1632 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Lin28 1632

分子量 281.31
公式 C15H15N5O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 108825-65-6
PubChem ID 2737312
InChI Key WPAQLESUVYGUJZ-UHFFFAOYSA-N
Smiles CN(C1=CC=CC(C2=NN3C(C)=NN=C3C=C2)=C1)C(C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Lin28 1632

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 28.13 100
ethanol 28.13 100

制备储备液 for Lin28 1632

以下数据基于产品分子量 281.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.55 mL 17.77 mL 35.55 mL
5 mM 0.71 mL 3.55 mL 7.11 mL
10 mM 0.36 mL 1.78 mL 3.55 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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产品说明书 for Lin28 1632

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Lin28 1632

参考文献是支持产品生物活性的出版物。

Roos et al (2016) A small-molecule inhibitor of Lin28. ACS Chem.Biol. 11 2773 PMID: 27548809

Chen et al (2019) LIN28/ let-7/PD-L1 pathway as a target for cancer immunotherapy. Cancer Immunol.Res. 7 487 PMID: 30651289

Chen et al (2019) Targeting LIN28B reprograms tumor glucose metabolism and acidic microenvironment to suppress cancer stemness and metastasis. Oncogene 38 4527 PMID: 30742065

If you know of a relevant reference for Lin28 1632, please let us know.

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关键词: Lin28 1632, Lin28 1632 supplier, Lin281632, RNA-binding, protein, Lin28, stem, cell, differentiation, bromodomains, inhibitors, inhibits, PD-L1, let-7, antitumor, immunity, Bromodomains, DNA,, RNA, and, Protein, Synthesis, ESCs, iPSC, Immune, Checkpoints, 6068, Tocris Bioscience

3 篇 Lin28 1632 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Lin28 1632 的部分引用包括：

Alfredo et al (2020) Functional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming. Front Cell Dev Biol 8 562940 PMID: 33330447

Miguel N et al (2020) LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma LIN28B Control of EWS-FLI1 Stability. Cell Rep 30 4567-4583.e5 PMID: 32234488

Yoji et al (2021) Lin28A/let-7 oncogenic circuit is a potential therapeutic target in neurocutaneous melanosis-associated CNS tumors in children. Neurooncol Adv 3 vdaa174 PMID: 33506207

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Lin28 1632 的评论

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Good inhibitor for Lin28.
By Satbir Thakur on 05/17/2021
分析类型： In Vitro
种属： Human
细胞系/组织： YP-MEL, T47D and BT183

Used as an inhibitor for Lin28 for 96 h in cell lines expressing Lin28. The protein level was then estimated using a western blot method.

PMID: 33506207 参考文献
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