Linezolid

Name: Linezolid
Brand: Tocris Bioscience
SKU: 3765
Rating: 4.5 (2 reviews)

Cat. No. 3765 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Antibiotic; inhibits protein synthesis in gram-positive bacteria

别名： PNU 100766,U 100766

化学名： N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide

纯度： ≥99% (HPLC)

说明书

引用文献

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Linezolid

Linezolid is an oxazolidinone antibiotic. Inhibits bacterial protein synthesis prior to chain initiation. Displays potent antibacterial activity against a variety of multidrug-resistant gram-positive microbes in vitro and in vivo. Identified as targeting human host cell proteins that interact with SARS-CoV-2.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for Linezolid

Linezolid is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Linezolid

分子量	337.35
公式	C₁₆H₂₀FN₃O₄
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	165800-03-3
PubChem ID	441401
InChI Key	TYZROVQLWOKYKF-ZDUSSCGKSA-N
Smiles	FC1=CC(N3C[C@H](CNC(C)=O)OC3=O)=CC=C1N2CCOCC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Linezolid

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	33.74	100
	ethanol	8.43	25

制备储备液 for Linezolid

以下数据基于产品分子量 337.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.82 mL	29.64 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
10 mM	0.3 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.3 mL	0.59 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

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产品说明书 for Linezolid

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Linezolid

参考文献是支持产品生物活性的出版物。

Brickner et al (1996) Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multi-drug-resistant gram-positive bacterial infections. J.Med.Chem. 39 673 PMID: 8576909

Ford et al (1996) In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections. Antimicrob.Agents Chemother. 40 1508 PMID: 8726028

Brickner et al (2008) Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. J.Med.Chem. 51 1981 PMID: 18338841

Gordon et al (2020) A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 583 PMID: 32353859

If you know of a relevant reference for Linezolid, please let us know.

按标靶查看相关产品

关键词: Linezolid, Linezolid supplier, PNU100766, U100766, antibacterial, antibiotics, gram-positive, bacteria, protein, synthesis, inhibitors, inhibits, Pfizer, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, PNU, 100766, U, DNA,, RNA, and, Protein, Synthesis, Antibiotics, Coronavirus, 3765, Tocris Bioscience

篇 Linezolid 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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Linezolid 的评论

平均评分: 4.5 (基于 2 条评论。)

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Used Linezolid to identify its effectivenes against MRSA infections.

By Anonymous on 02/18/2019

种属： Human

Used Linezolid to identify its effectivenes against MRSA infections caused by hospitalization.

Linezolid was used in resistance studies.

By Jade Smith on 02/05/2019

种属： Human

Linezolid was used in resistance studies. Antibiotic susceptibility testing was done for each isolate by the Kirby-Bauer disc diffusion method (DDM). The antibiotic works ideally and would use again.

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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