主页 / 药理学 / Enzymes / Kinases / RSK / RSK Inhibitors / LJI308

LJI308

Cat. No. 6754 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent pan-RSK inhibitor
化学名： 2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for LJI308

LJI308 is a potent pan-ribosomal S6 protein kinase (RSK) inhibitor (IC50 values are 4 to 13 nM). Displays selectivity for RSK isoforms over other kinases. Inhibits RSK-dependent Y-box binding protein 1 (YB-1) phosphorylation in vitro. Suppresses growth of triple negative breast cancer cell lines.

化合物库 for LJI308

LJI308 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for LJI308

分子量 368.38
公式 C21H18F2N2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1627709-94-7
PubChem ID 118704762
InChI Key YUYJEQHNWKQNBT-UHFFFAOYSA-N
Smiles OC1=C(C=C(C2=CN=CC=C2C3=CC=C(N4CCOCC4)C=C3)C=C1F)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LJI308

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.42 50

制备储备液 for LJI308

以下数据基于产品分子量 368.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.43 mL 27.15 mL 54.29 mL
2.5 mM 1.09 mL 5.43 mL 10.86 mL
5 mM 0.54 mL 2.71 mL 5.43 mL
25 mM 0.11 mL 0.54 mL 1.09 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for LJI308

参考文献是支持产品生物活性的出版物。

Jain et al (2015) Discovery of potent and selective RSK inhibitors as biological probes. J.Med.Chem. 58 6766 PMID: 26270416

Aronchik et al (2014) Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol.Cancer Res. 12 803 PMID: 24554780

Davies et al (2015) Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes chemoresistance by eliminating cancer stem cells. Oncotarget. 6 20570 PMID: 26011941

If you know of a relevant reference for LJI308, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 RSK Inhibitors

关键词: LJI308, LJI308 supplier, LJI, 308, RSK1, RSK2, RSK3, RSK4, inhibitors, inhibits, ribosome, S6, protein, kinase, potent, RSK, 6754, Tocris Bioscience

篇 LJI308 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 LJI308 的引用文献。 您是否知道使用了 Tocris LJI308 的优秀论文？ 请告知我们.

LJI308 的评论

目前没有该产品的评论。 Be the first to review LJI308 and earn rewards!

Have you used LJI308?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review