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说明： Potent and selective Chk1 inhibitor
化学名： N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy)phenyl]-N'-(5-methyl-2-pyrazinyl)urea
纯度： ≥98% (HPLC)
生物活性 for LY 2603618
LY 2603618 is a potent and selective Chk1 inhibitor (IC50 = 7 nM). Inhibits Chk1 autophosphorylation. Induces cell cycle arrest in the G2/M phase and induces the DNA damage response in lung cancer cells. Inhibits growth of NSCLC xenografts in mice when administered in combination with Pemetrexed (Cat.No. 6185).
化合物库 for LY 2603618
LY 2603618 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for LY 2603618
| 分子量 | 436.3 |
| 公式 | C18H22BrN5O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 911222-45-2 |
| PubChem ID | 11955855 |
| InChI Key | SYYBDNPGDKKJDU-ZDUSSCGKSA-N |
| Smiles | CC1=CN=C(C=N1)NC(NC2=C(C=C(C(Br)=C2)C)OC[C@@H]3CNCCO3)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for LY 2603618
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 8.73 | 20 |
制备储备液 for LY 2603618
以下数据基于产品分子量 436.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.46 mL | 57.3 mL | 114.6 mL |
| 1 mM | 2.29 mL | 11.46 mL | 22.92 mL |
| 2 mM | 1.15 mL | 5.73 mL | 11.46 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.29 mL |
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产品说明书 for LY 2603618
参考文献 for LY 2603618
参考文献是支持产品生物活性的出版物。
Wang et al (2014) The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Apoptosis 19 1389 PMID: 24928205
Calvo et al (2014) Preclinical analyses and phase I evaluation of LY2603618 administered in combination with pemet. and cisp. in patients with advanced cancer. Invest.New Drugs 32 955 PMID: 24942404
If you know of a relevant reference for LY 2603618, please let us know.
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关键词: LY 2603618, LY 2603618 supplier, LY2603618, checkpoint, Chk1, inhibitors, inhibits, potent, selective, DNA, damage, response, cell, cycle, arrest, Checkpoint, Control, Kinases, 6454, Tocris Bioscience
1 篇 LY 2603618 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LY 2603618 的部分引用包括：
Adam M et al (2022) Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury. Sci Adv 8 eabq2611 PMID: 36103534
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.