LYN 1604 dihydrochloride

Cat. No. 6617 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent UNC-51-like kinase 1 (ULK1) agonist

化学名： 2-[Bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]ethanone dihydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for LYN 1604 dihydrochloride

LYN 1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) agonist (EC₅₀ = 18.94 nM). In MDA-MB-231 cells, LYN 1604 induces upregulation of Beclin-1, LC3-I and LC3-II, as well as degradation of p62. LYN 1604 induces cell death (IC₅₀ = 1.66 μM) via the ULK complex involving both autophagy and apoptosis pathway effectors (e.g. ATF3, RAD21, and caspase-3); this effect is reversible by the autophagy inhibitor 3-methyladenine (Cat. No. 3977). LYN 1604 inhibits tumor growth in a mouse xenograft model, decreases bone loss in a mouse model of osteoporosis and reduces the formation of TRAP-positive multinucleated cells.

技术数据 for LYN 1604 dihydrochloride

分子量	657.54
公式	C₃₃H₄₃Cl₂N₃O₂.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2310109-38-5
PubChem ID	131954512
InChI Key	GZCBLOPFZPJUOQ-UHFFFAOYSA-N
Smiles	O=C(CN(CC(C)C)CC(C)C)N1CCN(CC(C2=CC=C(C=C2Cl)Cl)OCC3=CC4=C(C=CC=C4)C=C3)CC1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LYN 1604 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	ethanol	6.58	10

制备储备液 for LYN 1604 dihydrochloride

以下数据基于产品分子量 657.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	15.21 mL	76.04 mL	152.08 mL
0.5 mM	3.04 mL	15.21 mL	30.42 mL
1 mM	1.52 mL	7.6 mL	15.21 mL
5 mM	0.3 mL	1.52 mL	3.04 mL

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产品说明书 for LYN 1604 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for LYN 1604 dihydrochloride

参考文献是支持产品生物活性的出版物。

Zhang et al (2021) ULK1 suppresses osteoclast differentiation and bone resorption via inhibiting Syk-JNK through DOK3. Oxid.Med.Cell Longev. 2021 2896674 PMID: 34820053

Zhang et al (2018) UNC-51-like Kinase 1: from an autophagic initiator to multifunctional drug target. J.Med.Chem. 61 6491 PMID: 29509411

Zhang et al (2017) Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem.Sci. 8 2687 PMID: 28553505

If you know of a relevant reference for LYN 1604 dihydrochloride, please let us know.

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关键词: LYN 1604 dihydrochloride, LYN 1604 dihydrochloride supplier, LYN1604, potent, UNC-51-like, kinase, 1, ULK1, agonists, agonism, activators, activates, autophagy, apoptosis, Other, Kinases, Autophagy, Apoptosis, Inducers, 6617, Tocris Bioscience

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