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Maritoclax

Cat. No. 5368 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

This product has been withdrawn from sale and is superseded by A 1210477 (Cat. No. 6409)
说明： Mcl-1 inhibitor; proapoptotic
化学名： 1,1'-(4,4',5,5'-Tetrachloro[1,3'-bi-1H-pyrrole]-2,2'-diyl)bis[1-2-hydroxyphenyl)methanone
纯度： ≥97% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Maritoclax

Mcl-1 inhibitor; disrupts Mcl-1-Bim interaction and induces Mcl-1 proteasomal degradation. Exhibits no effect on Bcl-XL-Bim interaction. Selectively induces apoptosis in Mcl-1-dependent K562 leukemia cells. Sensitizes K562 and Raji cells to ABT-737-induced apoptosis.

技术数据 for Maritoclax

分子量 510.15
公式 C22H12Cl4N2O4
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 1227962-62-0
PubChem ID 24797083
InChI Key QYPJBTMRYKRTFG-UHFFFAOYSA-N
Smiles ClC1=C(Cl)C(N2C(C(C4=C(O)C=CC=C4)=O)=CC(Cl)=C2Cl)=C(C(C3=C(O)C=CC=C3)=O)N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

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关键词: Maritoclax, Maritoclax supplier, Mcl-1, inhibitors, inhibits, apoptosis, proapoptotic, leukemia, ABT737, marinopyrroleA, Bcl-2, Family, 5368, Tocris Bioscience

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