主页 / 细胞生物学 / Regulated Cell Death / Apoptosis / Bcl-2 Family / Bcl-2 Family Inhibitors / MIM1

MIM1

Cat. No. 4762 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4762 has been discontinued.

View all Bcl-2 Family products.
说明： Mcl-1 inhibitor; proapoptotic
化学名： 4-(E)-[[(2Z)-2-cyclohexylimino)-4-methyl-1,3-thiazol-3(2H)-yl]imino]methyl]benzene-1,2,3-triol
说明书
引用文献 (1)
评论
文献 (2)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for MIM1

MIM1 is an inhibitor of Mcl-1. Inhibits Mcl-1 indirectly by induction of the proapoptotic Mcl-1 ligand NOXA via the unfolded protein response (UPR) pathway. Sensitizes leukemia cells to the Bcl-2 inhibitor venetoclax (ABT-199). Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro.

技术数据 for MIM1

分子量 347.43
公式 C17H21N3O3S
储存 Store at +4°C
PubChem ID 135875424
InChI Key RGGFUBMUOVFZEF-DLHVAJNCSA-N
Smiles CC2=CS/C(N2/N=C/C3=CC=C(O)C(O)=C3O)=N\C1CCCCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for MIM1

参考文献是支持产品生物活性的出版物。

Cohen et al (2012) A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem.Biol. 19 1175 PMID: 22999885

Mallick et al (2019) Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477. Cell Death Dis. 10 185 PMID: 30796196

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Bcl-2 Family Inhibitors

关键词: MIM1, MIM1 supplier, Mcl-1, inhibitors, inhibits, proapoptotic, induces, apoptosis, caspases, activation, NOXA, Bcl-2, Family, 4762, Tocris Bioscience

1 篇 MIM1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MIM1 的部分引用包括：

Li et al (2014) The androgen receptor mediates antiapoptotic function in myometrial cells. Autophagy 5 e1338 PMID: 25032861

MIM1 的评论

目前没有该产品的评论。 Be the first to review MIM1 and earn rewards!

Have you used MIM1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for MIM1

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.