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Mitomycin C

Cat. No. 3258 5 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： DNA cross-linking antitumor agent
别名： Ametycine
化学名： [1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
纯度： ≥98% (HPLC)
说明书
引用文献 (5)
评论 (1)
文献 (1)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Mitomycin C

Mitomycin C is an antibiotic and antitumor agent. Covalently binds DNA forming intra- and interstrand crosslinks. Inhibits DNA synthesis. Also used for MEF/STO feeder layer preparation in stem cell culture.

技术数据 for Mitomycin C

分子量 334.33
公式 C15H18N4O5
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 50-07-7
PubChem ID 5746
InChI Key NWIBSHFKIJFRCO-WUDYKRTCSA-N
Smiles O=C(C(N)=C1C)C2=C(N(C[C@H]4[C@@H]3N4)[C@@]3(OC)[C@@H]2COC(N)=O)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Mitomycin C

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 0.33 1
DMSO 33.43 100

制备储备液 for Mitomycin C

以下数据基于产品分子量 334.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.99 mL 14.96 mL 29.91 mL
5 mM 0.6 mL 2.99 mL 5.98 mL
10 mM 0.3 mL 1.5 mL 2.99 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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产品说明书 for Mitomycin C

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Mitomycin C

参考文献是支持产品生物活性的出版物。

Tomasz et al (1987) Isolation and structure of a covalent cross-link adduct between mito. C and DNA. Science 235 1204 PMID: 3103215

Bizanek et al (1992) Isolation and structure of an intrastrand cross-link adduct of mito. C and DNA. Biochemistry 31 3084 PMID: 1554696

Bryja et al (2006) Derivation of mouse embryonic stem cells. Nat.Protoc. 1 2082 PMID: 17487198

Park et al (2016) Modeling and correction of structural variations in patient-derived iPSCs using CRISPR/Cas9. Nat.Protoc. 11 2154 PMID: 27711053

If you know of a relevant reference for Mitomycin C, please let us know.

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关键词: Mitomycin C, Mitomycin C supplier, inhibitors, inhibits, DNA, synthesis, cross-linking, antitumor, agents, Apoptosis, Inducer, MitomycinC, antibiotics, chemotherapeutics, stem, cells, feeder, layers, preparation, culture, Ametycine, Inducers, DNA,, RNA, and, Protein, Synthesis, Antibiotics, Stem, Cell, Signaling, 3258, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Mitomycin C, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

5 篇 Mitomycin C 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Mitomycin C 的部分引用包括：

Woo et al (2015) Elucidating Compound Mechanism of Action by Network Perturbation Analysis. Cell 162 441 PMID: 26186195

Reinhardt et al (2013) Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. PLoS One 8 e59252 PMID: 23533608

Stepp et al (2018) Molecular basis of MMC enhanced corneal sensory nerve repair after debridement wounding. Sci Rep 8 16960 PMID: 30446696

Kishinevsky et al (2018) HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain DA neurons. Nat Commun 9 4345 PMID: 30341316

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Mitomycin C 的评论

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itotically inactivates mouse embryonic fibroblasts (MEFs) inactivated by Mitomycin treatment.
By Harry Clarke on 02/03/2019
种属： Human

For studying cell cycle arrest Mitomycin has been used. MEFs have been inactivated with Mitomycin treatment.

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Pathways for Mitomycin C

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Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.