MK 2206 dihydrochloride

Cat. No. 7850 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective allosteric Akt1, Akt2 and Akt3 inhibitor

化学名： 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride

纯度： ≥98% (HPLC)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for MK 2206 dihydrochloride

MK 2206 dihydrochloride is a potent and selective allosteric Akt inhibitor (IC₅₀ values are 5 nM, 12 nM, and 65 nM for Akt1, Akt2, and Akt3, respectively). MK 2206 requires the Pleckstrin homology domain for its activity, and exhibits no inhibitory activity in a panel of 250 tested protein kinases. MK 2206 induces growth inhibition of different cancer cell lines (IC₅₀ in the range 3.4 and 28.6 μmol/L) and enhances antitumor efficacy of a range of standard chemotherapeutics. It synergistically inhibits cell proliferation of human lung and breast cancer cells in combination with Erlotinib (Cat. No. 7194) by suppressing both the Ras/Erk and PI 3-K pathways in vitro and in vivo. MK 2206 can be used to block the IL-22 - Akt signaling pathway for studying paneth cell differentiation.

技术数据 for MK 2206 dihydrochloride

分子量	480.39
公式	C₂₅H₂₁N₅O.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1032350-13-2
PubChem ID	46930998
InChI Key	HWUHTJIKQZZBRA-UHFFFAOYSA-N
Smiles	O=C1NN=C2C3=C(C=CN12)N=C(C4=CC=C(C5(CCC5)N)C=C4)C(C6=CC=CC=C6)=C3.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MK 2206 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	24.02	50

制备储备液 for MK 2206 dihydrochloride

以下数据基于产品分子量 480.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.16 mL	20.82 mL	41.63 mL
2.5 mM	0.83 mL	4.16 mL	8.33 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
25 mM	0.08 mL	0.42 mL	0.83 mL

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产品说明书 for MK 2206 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MK 2206 dihydrochloride

参考文献是支持产品生物活性的出版物。

He et al (2022) Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation. Cell Stem Cell 29 1333 PMID: 36002022

Hirai et al (2010) MK-2206, an allosteric Akt Inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol.Cancer Ther. 9 1956 PMID: 20571069

Li et al (2009) Abstract #DDT01-1: MK-2206: A potent oral allosteric AKT inhibitor. AACR Annual Meeting 69

If you know of a relevant reference for MK 2206 dihydrochloride, please let us know.

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关键词: MK 2206 dihydrochloride, MK 2206 dihydrochloride supplier, MK2206, dihydrochloride, 2HCl, MK-2206, potent, selective, allosteric, AKT1, AKT2, AKT3, kinase, inhibitor, antitumor, Akt, (Protein, Kinase, B), 7850, Tocris Bioscience

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