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ML 311

Cat. No. 5733 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5733 has been discontinued.

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说明： Inhibits Mcl-1-BIM interaction
化学名： 7-[(4-Ethyl-1-piperazinyl)[4-(trifluoromethyl)phenyl]methyl]-8-quinolinol
纯度： ≥99% (HPLC)
说明书
引用文献
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文献 (2)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for ML 311

ML 311 is an inhibits Mcl1-BIM interaction. Inhibits viability of Mcl1-dependent tumor cell lines. Induces cell death and decreased spheroid formation in Her2 positive breast cancer cells.

技术数据 for ML 311

分子量 415.45
公式 C23H24F3N3O
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 315698-17-0
PubChem ID 3384730
InChI Key NGAPBLRRJSKIRT-UHFFFAOYSA-N
Smiles CCN(CC1)CCN1C(C2=CC=C(C(F)(F)F)C=C2)C3=C(O)C4=NC=CC=C4C=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for ML 311

参考文献是支持产品生物活性的出版物。

Bashari et al (2016) Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications. Breast Cancer Res. 18 26 PMID: 26921175

Bannister et al (2012) ML311: A small molecule that potently and selectively disrupts the protein-protein interaction of Mcl-1 and Bim: a probe for studying lymphoid tumorigenesis. Probe Reports from the NIH Molecular Libraries Program PMID: 23762927

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关键词: ML 311, ML 311 supplier, ML311, myeloid, cell, leukemia, 1, mcl1, BIM, inhibitors, inhibits, interaction, Bcl-2, Family, 5733, Tocris Bioscience

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Programmed Cell Death Poster

Programmed Cell Death Poster

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Pathways for ML 311

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.