ML 315 hydrochloride

Cat. No. 5700 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Inhibitor of Clk and DYRK kinases

化学名： 5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinamine hydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ML 315 hydrochloride

ML 315 hydrochloride is a inhibitor of cdc2-like kinases (Clk) and DYRK kinases (IC₅₀ values are 68, 68 and 231 nM for Clk1, Clk4 and Clk2, respectively, and 282 and 1156 nM for Dyrk1A and Dyrk1B). Shows 20-fold selectivity for Clk4 over Dyrk1A. Stable in both mouse and human plasma. Moderately cell permeable.

化合物库 for ML 315 hydrochloride

ML 315 hydrochloride is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 315 hydrochloride

分子量	410.68
公式	C₁₈H₁₃Cl₂N₃O₂.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1440251-53-5
PubChem ID	127021037
InChI Key	MNCDEAAKKQCKSX-UHFFFAOYSA-N
Smiles	ClC1=CC(CNC2=NC=NC=C2C3=CC=C(OCO4)C4=C3)=CC(Cl)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 315 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	37.42	100
	ethanol	18.71	50

制备储备液 for ML 315 hydrochloride

以下数据基于产品分子量 410.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.17 mL	24.35 mL
5 mM	0.49 mL	2.43 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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产品说明书 for ML 315 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ML 315 hydrochloride

参考文献是支持产品生物活性的出版物。

Coombs et al (2013) Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg.Med.Chem.Lett. 23 3654 PMID: 23642479

If you know of a relevant reference for ML 315 hydrochloride, please let us know.

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关键词: ML 315 hydrochloride, ML 315 hydrochloride supplier, ML315, HCl, Inhibitors, Inhibits, Cdc2-like, kinases, Clk, kinase, Dual, specificity, tyrosine, phosphorylation-regulated, DYRK, CLK, (Cdc2-like, kinases), 5700, Tocris Bioscience

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