ML 9 hydrochloride

Cat. No. 0431 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Myosin light chain kinase inhibitor

化学名： 1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride

纯度： ≥98% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ML 9 hydrochloride

ML 9 hydrochloride is a selective MLCK inhibitor (K_i values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca²⁺ entry (SOCE).

化合物库 for ML 9 hydrochloride

ML 9 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 9 hydrochloride

分子量	361.29
公式	C₁₅H₁₇ClN₂O₂S.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	105637-50-1
PubChem ID	108047
InChI Key	ZNRYCIVTNLZOGI-UHFFFAOYSA-N
Smiles	Cl.ClC1=C2C=CC=C(C2=CC=C1)S(=O)(=O)N1CCCNCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 9 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	9.03	25

制备储备液 for ML 9 hydrochloride

以下数据基于产品分子量 361.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.25 mM	11.07 mL	55.36 mL	110.71 mL
1.25 mM	2.21 mL	11.07 mL	22.14 mL
2.5 mM	1.11 mL	5.54 mL	11.07 mL
12.5 mM	0.22 mL	1.11 mL	2.21 mL

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产品说明书 for ML 9 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ML 9 hydrochloride

参考文献是支持产品生物活性的出版物。

Hidaka and Koybashi (1992) Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 32 377 PMID: 1605572

Seto et al (1991) Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle. Eur.J.Pharmacol. 195 267 PMID: 1874276

Varnai et al (2009) STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 30 118 PMID: 19187978

Hidaka and Hagiwara (1987) Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors. Trends Pharmacol.Sci. 8 162

If you know of a relevant reference for ML 9 hydrochloride, please let us know.

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