主页 / 药理学 / Enzymes / Kinases / Src Kinases / Src Kinase Activators / MLR 1023

MLR 1023

Cat. No. 4582 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective allosteric activator of Lyn kinase
化学名： 5-(3-Methylphenoxy)-2(1H)-pyrimidinone
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MLR 1023

MLR 1023 is a selective allosteric activator of Lyn kinase (EC50 = 63 nM); displays no significant activity against a range of 47 other kinases, including other Src family kinases such as Fyn, Lck and Src kinase. Reduces blood glucose levels without affecting in vivo insulin secretion. Orally bioavailable.

化合物库 for MLR 1023

MLR 1023 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for MLR 1023

分子量 202.21
公式 C11H10N2O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 41964-07-2
PubChem ID 39065
InChI Key HJQILFPVRNHTIG-UHFFFAOYSA-N
Smiles CC1=CC(OC2=CNC(N=C2)=O)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MLR 1023

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 20.22 100
ethanol 4.04 20

制备储备液 for MLR 1023

以下数据基于产品分子量 202.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.95 mL 24.73 mL 49.45 mL
5 mM 0.99 mL 4.95 mL 9.89 mL
10 mM 0.49 mL 2.47 mL 4.95 mL
50 mM 0.1 mL 0.49 mL 0.99 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for MLR 1023

参考文献是支持产品生物活性的出版物。

Ochman et al (2012) The Lyn kinase activator MLR-1023 is a novel Ins receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J.Pharmacol.Exp.Ther. 342 23 PMID: 22431203

Saporito et al (2012) MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J.Pharmacol.Exp.Ther. 342 15 PMID: 22473614

If you know of a relevant reference for MLR 1023, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Src Kinase Activators

关键词: MLR 1023, MLR 1023 supplier, MLR1023, type, II, diabetes, antidiabetic, hyperglycemia, lyn, kinase, inhibitors, inhibits, selective, Src, Kinases, 4582, Tocris Bioscience

2 篇 MLR 1023 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MLR 1023 的部分引用包括：

Iida et al (2019) Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy. Nat Commun 10 4262 PMID: 31537808

Konstantinos et al (2021) Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis. Nat Commun 12 2424 PMID: 33893293

您是否知道使用了 Tocris MLR 1023 的优秀论文？ 请告知我们.

MLR 1023 的评论

目前没有该产品的评论。 Be the first to review MLR 1023 and earn rewards!

Have you used MLR 1023?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review