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MP A08

Cat. No. 5803 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5803 has been discontinued.

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说明： Selective ATP competitive SphK1 and 2 inhibitor; cell permeable
别名： NSC 122314
化学名： 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide
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生物活性 技术数据 说明书 参考文献

生物活性 for MP A08

MP A08 is a selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Ki values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.

技术数据 for MP A08

分子量 519.64
公式 C27H25N3O4S2
储存 Store at -20°C
CAS Number 219832-49-2
PubChem ID 420266
InChI Key FLDBNMYJUMAXDQ-UHFFFAOYSA-N
Smiles O=S(NC1=CC=CC=C1/N=C/C2=CC=CC=C2NS(C3=CC=C(C)C=C3)(=O)=O)(C4=CC=C(C)C=C4)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for MP A08

参考文献是支持产品生物活性的出版物。

Pitman et al (2015) A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget 6 7065 PMID: 25788259

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关键词: MP A08, MP A08 supplier, MPA08, Selective, ATP, competitive, sphingosine, kinase, 1, and, 2, SphK, sk1, sk2, cell, permeable, anticancer, apoptosis, apoptotic, NSC122314, NSC, 122314, Sphingosine, Kinase, 5803, Tocris Bioscience

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