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MR 24

Cat. No. 8122 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective MST3 kinase binding inhibitor
化学名： 8-(4-Aminobutyl)-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(1,3-dihydroxypropan-2-ylamino)pyrido[2,3-d]pyrimidin-7-one trihydrochloride
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MR 24

MR 24 is a potent and selective MST3 kinase binding inhibitor with >10 fold selectivity over MST4 (EC50 values from NanoBRET assay are 57 nM and 583 nM for MST3 and MST4 respectively). MR 24 increases the number of cells in G1 phase of cell cycle, is non-cytotoxic and cell permeable. Shows 90% stability over 1 hour in activated liver microsomes in vivo.

技术数据 for MR 24

分子量 618.38
公式 C26H29ClN6O3.3HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
InChI Key GDJVKNSFYAPEKT-UHFFFAOYSA-N
Smiles CC1=CC=CC(C2=CC(Cl)=C(C3=CC(C=NC(NC(CO)CO)=N4)=C4N(CCCCN)C3=O)C=C2)=N1.Cl.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MR 24

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.92 50

制备储备液 for MR 24

以下数据基于产品分子量 618.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 3.23 mL 16.17 mL 32.34 mL
2.5 mM 0.65 mL 3.23 mL 6.47 mL
5 mM 0.32 mL 1.62 mL 3.23 mL
25 mM 0.06 mL 0.32 mL 0.65 mL

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参考文献 for MR 24

参考文献是支持产品生物活性的出版物。

Rak et al (2024) Development of selective pyrido[2,3.d]pyrimidin-7(8H).one-based mammalian STE20-Like (MST3/4) kinase inhibitors. J.Med.Chem. 67 3813

If you know of a relevant reference for MR 24, please let us know.

按标靶查看相关产品

关键词: MR 24, MR 24 supplier, MR24, MST3, MST4, inhibitor, inhibitors, mammalian, STE20-like, protein, kinase, 3, STK24, ser, thr, ser/thr, Other, Kinases, Cell, Cycle, Inhibitors, 8122, Tocris Bioscience

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