MRT 67307 dihydrochloride

Cat. No. 5134 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Salt inducible kinase (SIK) inhibitor; also ULK1 and 2 inhibitor

化学名： N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for MRT 67307 dihydrochloride

MRT 67307 dihydrochloride is a salt inducible kinase (SIK) inhibitor (IC₅₀ values are 67, 250 and 430 nM for SIK2, SIK1 and SIK3 respectively) and a potent inhibitor of ULK1 and 2 (IC₅₀ values of 45 and 38 nM, respectively). MRT 67307 dihydrochloride also inhibits TBK1, MARK1-4, IKKε and NUAK1 (IC₅₀ values are 19, 27-52, 160 and 230 nM respectively). Has no effect on IKKα or IKKβ. Induces IL-10 secretion and inhibits TNF-α and IL-6 secretion in bacterial LPS-stimulated macrophages. Also enhances IL-1-induced activation of NFκB-dependent gene transcription in mouse embryonic fibroblast (MEF) cells. Inhibits autophagy.

技术数据 for MRT 67307 dihydrochloride

分子量	537.52
公式	C₂₆H₃₆N₆O₂.2HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1781882-89-0
PubChem ID	90489013
InChI Key	ZIKXPHATVRPOQG-UHFFFAOYSA-N
Smiles	O=C(C5CCC5)NCCCNC1=C(C4CC4)C=NC(NC2=CC(CN3CCOCC3)=CC=C2)=N1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MRT 67307 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	10.75	20
	DMSO	53.75	100

制备储备液 for MRT 67307 dihydrochloride

以下数据基于产品分子量 537.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.3 mL	18.6 mL
5 mM	0.37 mL	1.86 mL	3.72 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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产品说明书 for MRT 67307 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MRT 67307 dihydrochloride

参考文献是支持产品生物活性的出版物。

et al (2011) Novel cross-talk Biochem.J. 93 et al (2017) Pharmacological Nat.Rev.Drug.Discov. 487 Clark of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Acad.Sci.U.S.A. 109 PMID: 23033494

ight">Clark within the IKK family controls innate immunity. 434 PMID: 21138416

ight">Smith of TBK1 and IKKe in the expression and activation of Pellino 1. 434 PMID: 21204785

ight">Galluzzi modulation of autophagy: therapeutic potential and persisting obstacles. 16 PMID: 28529316

ight">Petherick inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. 290 PMID: 26614783 you know of a relevant reference for MRT 67307 dihydrochloride, please let us know.

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关键词: MRT 67307 dihydrochloride, MRT 67307 dihydrochloride supplier, MRT67307, dihydrochloride, salt, inducible, kinase, SIK, inhibitors, inhibits, TBK1, IKKε, IKKepsilon, IKKe, MARK, NUAK, ULK1, 2, autophagy, Other, Kinases, Autophagy, TANK, binding, (TBK), 5134, Tocris Bioscience

1 篇 MRT 67307 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MRT 67307 dihydrochloride 的部分引用包括：

Alison et al (2020) LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells. Autophagy 16 1314-1331 PMID: 31651224

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