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MRT 68921 dihydrochloride

Cat. No. 5780 6 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： ULK inhibitor
化学名： N-[3-[[5-Cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (6)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MRT 68921 dihydrochloride

MRT 68921 dihydrochloride is a potent ULK inhibitor (IC50 values are 1.1 and 2.9 nM for ULK2 and ULK1, respectively). Inhibits autophagy in mouse embryonic fibroblasts.

技术数据 for MRT 68921 dihydrochloride

分子量 507.5
公式 C25H34N6O.2HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 2080306-21-2
PubChem ID 124201611
InChI Key NLKPLTWKINJHCK-UHFFFAOYSA-N
Smiles CN1CCC2=CC(NC3=NC=C(C(NCCCNC(C4CCC4)=O)=N3)C5CC5)=CC=C2C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MRT 68921 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 50.75 100

制备储备液 for MRT 68921 dihydrochloride

以下数据基于产品分子量 507.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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产品说明书 for MRT 68921 dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for MRT 68921 dihydrochloride

参考文献是支持产品生物活性的出版物。

Petherick et al (2015) Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J.Biol.Chem. 290 11376 PMID: 25833948

If you know of a relevant reference for MRT 68921 dihydrochloride, please let us know.

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关键词: MRT 68921 dihydrochloride, MRT 68921 dihydrochloride supplier, MRT68921, dihydrochloride, ULK1, 2, inhibitors, inhibits, autophagy, potent, Other, Kinases, Autophagy, 5780, Tocris Bioscience

6 篇 MRT 68921 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MRT 68921 dihydrochloride 的部分引用包括：

Andreas et al (2023) Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity. Transl Psychiatry 13 143 PMID: 37137886

Patricia et al (2022) Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration. Nat Commun 13 4220 PMID: 35864098

Pia et al (2021) Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells. Cells 10 PMID: 33673037

Jesse C et al (2021) Endoplasmic reticulum tubules limit the size of misfolded protein condensates. Elife 10 PMID: 34467852

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