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MSC 1186

Cat. No. 7927 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective SRPK family inhibitor
化学名： N-[3-[[[2-(6-Chloro-7-fluoro-1H-benzimidazol-2-yl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MSC 1186

MSC1186 is a potent and selective inhibitor of serine arginine protein kinases (SRPK) 3, 1 and 2 (IC50 values are 0.6 nM, 3 nM and 81 nM respectively in biochemical assay; EC50 values in NanoBRETassay are 40 nM, 98 nM and 149 nM, respectively). Shows no activity at CLK and DYRK families (IC50 >10 μM).

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MSC 1186 probe summary on the SGC website.

External Portal Information for MSC 1186

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MSC 1186 is reviewed on the chemical probes website.

技术数据 for MSC 1186

分子量 461.9
公式 C19H17ClFN7O2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2871698-23-4
PubChem ID 162368309
InChI Key WBFJDKLBAAHKIL-UHFFFAOYSA-N
Smiles O=S(N(C)C1=NC=CC=C1CNC2=NC(C3=NC4=C(N3)C(F)=C(Cl)C=C4)=NC=C2)(C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MSC 1186

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.09 50

制备储备液 for MSC 1186

以下数据基于产品分子量 461.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.33 mL 21.65 mL 43.3 mL
2.5 mM 0.87 mL 4.33 mL 8.66 mL
5 mM 0.43 mL 2.16 mL 4.33 mL
25 mM 0.09 mL 0.43 mL 0.87 mL

Molarity Calculator

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参考文献 for MSC 1186

参考文献是支持产品生物活性的出版物。

Schröder et al (2023) MSC-1186, a highly selective pan-SRPK inhibitor based on an exceptionally decorated benzimidazole-pyrimidine core. J.Med.Chem. 66 837 PMID: 36516476

If you know of a relevant reference for MSC 1186, please let us know.

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关键词: MSC 1186, MSC 1186 supplier, MSC1186, SRPK, serine, arginine, protein, kinases, kinase, SRPK1, 2, SRPK3, potent, and, selective, Other, Kinases, 7927, Tocris Bioscience

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