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MSC 2032964A

Cat. No. 5641 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective ASK1 inhibitor; orally bioavailable
化学名： N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide
纯度： ≥97% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MSC 2032964A

MSC 2032964A is a potent and selective ASK1 inhibitor (IC50 = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant.

化合物库 for MSC 2032964A

MSC 2032964A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for MSC 2032964A

分子量 362.31
公式 C16H13F3N6O
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 1124381-43-6
PubChem ID 25214468
InChI Key XUKGFHHTSUKORV-UHFFFAOYSA-N
Smiles O=C(C1=CC=CN=C1)NC2=NN3C(C=C(C(F)(F)F)C=C3NC4CC4)=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MSC 2032964A

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.25 20
ethanol 3.62 10 温和加热

制备储备液 for MSC 2032964A

以下数据基于产品分子量 362.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 13.8 mL 69 mL 138 mL
1 mM 2.76 mL 13.8 mL 27.6 mL
2 mM 1.38 mL 6.9 mL 13.8 mL
10 mM 0.28 mL 1.38 mL 2.76 mL

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产品说明书 for MSC 2032964A

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for MSC 2032964A

参考文献是支持产品生物活性的出版物。

Guo et al (2010) Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol.Med. 2 504 PMID: 21064192

If you know of a relevant reference for MSC 2032964A, please let us know.

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关键词: MSC 2032964A, MSC 2032964A supplier, MSC2032964A, apoptosis, signal, regulating, kinase, 1, ASK1, inhibits, inhibitors, potent, selective, orally, bioavailable, neuroinflammation, EAE, experimental, autoimmune, encephalomyelitis, 5641, Tocris Bioscience

2 篇 MSC 2032964A 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MSC 2032964A 的部分引用包括：

Xochitl et al (2021) IRE1α RIDD activity induced under ER stress drives neuronal death by the degradation of 14-3-3 θ mRNA in cortical neurons during glucose deprivation. Cell Death Discov 7 131 PMID: 34083523

Ju-Ri et al (2020) IRE1α kinase-mediated unconventional protein secretion rescues misfolded CFTR and pendrin. Sci Adv 6 eaax9914 PMID: 32128399

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