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MTK 458

Cat. No. 7980 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： PINK1 activator
化学名： N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MTK 458

MTK 458 is a brain penetrant PTEN-induced kinase 1 (PINK1) activator. It binds to and stabilizes the active form of PINK1, increasing its activity and activating mitophagy downstream. It mediates clearance of pathogenic α-synuclein and normalizes pS65-Ubiquitin (pUb) in in vivo Parkinson's models. MTK458 is orally bioavailable.

许可信息

Sold with kind permission of Mitokinin

技术数据 for MTK 458

分子量 332.33
公式 C17H15F3N4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2499962-58-0
PubChem ID 155187445
InChI Key JOIONRWKOGDQOG-CYBMUJFWSA-N
Smiles FC(F)(F)C1=CC(C(N1)=NC=N2)=C2N[C@H]3C4=CC=CC=C4CCC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MTK 458

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 16.62 50
ethanol 6.65 20

制备储备液 for MTK 458

以下数据基于产品分子量 332.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 6.02 mL 30.09 mL 60.18 mL
2.5 mM 1.2 mL 6.02 mL 12.04 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
25 mM 0.12 mL 0.6 mL 1.2 mL

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参考文献 for MTK 458

参考文献是支持产品生物活性的出版物。

Chin et al (2023) Pharmacological PINK1 activation ameliorates pathology in Parkinson's disease models. bioRxiv PMID: 36824886

If you know of a relevant reference for MTK 458, please let us know.

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关键词: MTK 458, MTK 458 supplier, MTK458, PINK1, alpha-synuclein, a-synuclein, toxicity, Parkinsons, disease, parkinson's, in, vivo, brain, penetrant, orally, bioavailable, ubiquitin, activator, mitophagy, pUB, Other, Kinases, 7980, Tocris Bioscience

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