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说明： Activator of SUMO-activating enzyme, E1 ligase
化学名： 4-Methoxy-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl-2-benzothiazolamine
纯度： ≥98% (HPLC)
生物活性 for N106
N106 is an activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro. Improves ventricular function in a mouse model of heart disease.
技术数据 for N106
| 分子量 | 354.38 |
| 公式 | C17H14N4O3S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 862974-25-2 |
| PubChem ID | 3236395 |
| InChI Key | FBCSWQRNKAYAGY-UHFFFAOYSA-N |
| Smiles | COC1=C(N=C(NC2=NN=C(C3=CC=C(OC)C=C3)O2)S4)C4=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for N106
参考文献 for N106
参考文献是支持产品生物活性的出版物。
Kho et al (2015) Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nat.Commun. 6 7229 PMID: 26068603
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关键词: N106, N106 supplier, SUMO-activating, enzymes, E1, ligases, SERCA2a, SUMOylation, heart, diseases, activators, Other, Ligases, 5681, Tocris Bioscience
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