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NG 25

Cat. No. 5429 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： TGF-β-activated kinase (TAK1) inhibitor
化学名： N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NG 25

NG 25 is a TGF-β-activated kinase (TAK1) inhibitor (IC50 = 149 nM). Also inhibits LYN, MAP4K2 and Abl kinase activity (IC50 values are 12.9, 21.7 and 75.2 nM, respectively). Suppresses CpG A and CpG B-stimulated secretion of IFN-α and TLR7/8 agonist CL097-stimulated secretion of IFN-β in Gen 2.2 leukemia cells in vitro.

许可信息

Sold under license from Dana-Farber Cancer Institute.

技术数据 for NG 25

分子量 537.58
公式 C29H30F3N5O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1315355-93-1
PubChem ID 53340664
InChI Key SMPGEBOIKULBCT-UHFFFAOYSA-N
Smiles CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(OC4=CC=NC5=C4C=CN5)=C(C)C=C3)=O)C=C2)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NG 25

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 10.75 20

制备储备液 for NG 25

以下数据基于产品分子量 537.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 9.3 mL 46.5 mL 93.01 mL
1 mM 1.86 mL 9.3 mL 18.6 mL
2 mM 0.93 mL 4.65 mL 9.3 mL
10 mM 0.19 mL 0.93 mL 1.86 mL

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参考文献 for NG 25

参考文献是支持产品生物活性的出版物。

Tan et al (2015) Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J.Med.Chem. 58 183 PMID: 25075558

Pauls et al (2012) Essential role for IKKβ in production of type 1 IF.s by plasmacytoid dendritic cells. J.Biol.Chem. 287 19216 PMID: 22511786

Dzamko et al (2012) The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. PLoS ONE 7 e39132 PMID: 22723946

If you know of a relevant reference for NG 25, please let us know.

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关键词: NG 25, NG 25 supplier, NG25, TAK1, TGFbeta, TGFb, TGFβ, activated, kinases, inhibitors, inhibits, MAP4K2, LYN, Abl, Other, Kinases, 5429, Tocris Bioscience

篇 NG 25 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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NG 25 的评论

平均评分: 5 (Based on 1 Review.)

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Works for kinase assays.
By Scott Scarneo on 02/06/2019
分析类型： In Vitro
种属： Human

Worked in vitro Kinase assay compared to other TAK1 inhibitors.

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