NH 125

Cat. No. 3439 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： CaM kinase III (eEF-2 kinase) inhibitor

化学名： 1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazolium iodide

说明书

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NH 125

NH 125 is an eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC₅₀ = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Decreases the viability of a variety of cancer cell lines (IC₅₀ values are 0.7 - 4.8 μM) and blocks G₁/S cell cycle progression. Shown to induce eEF-2 phosphorylation in cancer cells. Also an effective antibacterial agent; inhibits histidine protein kinase in vitro (IC₅₀ = 6.6 μM) and in vivo.

技术数据 for NH 125

分子量	524.56
公式	C₂₇H₄₅IN₂
储存	Desiccate at -20°C
CAS Number	278603-08-0
PubChem ID	10436839
InChI Key	RVWOHCBHAGBLLT-UHFFFAOYSA-M
Smiles	CC1=[N+](CCCCCCCCCCCCCCCC)C=CN1CC2=CC=CC=C2.[I-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NH 125

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	52.46	100
	ethanol	39.34	75

制备储备液 for NH 125

以下数据基于产品分子量 524.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.91 mL	9.53 mL	19.06 mL
5 mM	0.38 mL	1.91 mL	3.81 mL
10 mM	0.19 mL	0.95 mL	1.91 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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产品说明书 for NH 125

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NH 125

参考文献是支持产品生物活性的出版物。

Yamamoto et al (2001) Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis. Biosci.Biotechnol.Biochem. 65 2306 PMID: 11758928

Arora et al (2003) Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res. 63 6894 PMID: 14583488

Arora et al (2004) P-glycoprotein mediates resistance to histidine kinase inhibitors. Mol.Pharmacol. 66 460 PMID: 15322237

Chen (2011) 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J.Biol.Chem. 286 43951 PMID: 22020937

If you know of a relevant reference for NH 125, please let us know.

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关键词: NH 125, NH 125 supplier, CaM, kinase, III, CAMK, eEF-2, inhibitors, inhibits, Histidine, protein, kinases, Calmodulin-Activated, calmodulin-dependent, Protein, NH125, Kinase, Other, Kinases, 3439, Tocris Bioscience