Nicotinamide Riboside

Cat. No. 6018 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： NAD⁺ precursor; substrate for nicotinamide riboside kinases

化学名： 3-(Aminocarbonyl)-1-β-D-ribofuranosylpyridinium chloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Nicotinamide Riboside

Nicotinamide Riboside is an NAD⁺ precursor. It is a substrate for nicotinamide riboside kinases (NRK1/2). Nicotinamide Riboside shows neuroprotective effects in a mouse model of type 2 diabetes and improves mitochondrial function in muscle stem cells in aged mice. The compound also corrects non-alchoholic fatty liver disease phenotype induced by NAD⁺ deficiency or high-fat diet in mice. Orally bioavailable.

技术数据 for Nicotinamide Riboside

分子量	290.7
公式	C₁₁H₁₅ClN₂O₅
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	23111-00-4
PubChem ID	90480033
InChI Key	YABIFCKURFRPPO-IVOJBTPCSA-N
Smiles	NC(C1=C[N+]([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=CC=C1)=O.[Cl-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nicotinamide Riboside

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	29.07	100
	water	29.07	100

制备储备液 for Nicotinamide Riboside

以下数据基于产品分子量 290.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.44 mL	17.2 mL	34.4 mL
5 mM	0.69 mL	3.44 mL	6.88 mL
10 mM	0.34 mL	1.72 mL	3.44 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

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产品说明书 for Nicotinamide Riboside

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Nicotinamide Riboside

参考文献是支持产品生物活性的出版物。

Zhang et al (2016) NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science 352 1436 PMID: 27127236

Trammell et al (2016) Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice. Sci.Rep. 6 PMID: 27230286

Zhou et al (2016) Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. Br.J.Pharmacol. 173 2352 PMID: 27174364

If you know of a relevant reference for Nicotinamide Riboside, please let us know.

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关键词: Nicotinamide Riboside, Nicotinamide Riboside supplier, NAD+, nicotinamide, riboside, kinase, adenine, dinucleotides, vitamin, precursor, pyridine, nucleoside, NRK1, NRK2, Other, Kinases, Enzyme, Substrates, /, Activators, 6018, Tocris Bioscience

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